Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children

被引：43
|
作者：
Hussein, Atef G. [1 ]
Mohamed, Randa H. [1 ]
Alghobashy, Ashgan A. [2 ]
机构：
[1] Zagazig Univ, Fac Med, Dept Med Biochem, Zagazig, Egypt
[2] Zagazig Univ, Fac Med, Pedriatre Dept, Zagazig, Egypt
来源：
CELLULAR IMMUNOLOGY | 2012年 / 279卷 / 01期
关键词：
CYP2R1; CYP27B1; Polymorphism; Type; 1; diabetes; VITAMIN-D; 25-HYDROXYVITAMIN D-3; GRAVES-DISEASE; GENE; DEFICIENCY; EXPRESSION;
D O I：
10.1016/j.cellimm.2012.08.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
CYP2R1 (25 alpha-hydroxylase) catalyzes vitamin D-3 to 25-hydroxyvitamin D-3, while the CYP27B1 (1 alpha-hydroxylase) catalyzes the 25(OH)D-3 to 1, 25(OH)(2)D-3. 1, 25(OH)(2)D-3 prevents the development of autoimmune diabetes. We aimed to investigate CYP2R1 and CYP27B1 genes polymorphisms and susceptibility to type 1 diabetes in children. One hundred and twenty type 1 diabetic patients and One hundred and twenty controls were genotyped for CYP2R1 (rs10741657) and CYP27B1 (rs10877012) polymorphism. GG genotype of CYP2R1 increased risk to develop type 1 diabetes, and CC genotype of CYP27B1 increased risk to develop type 1 diabetes. Our finding suggested that GG genotype of CYP2R1 polymorphism and/or CC genotype of CYP27B1 polymorphism increased the risk of developing of type 1 diabetes in Egyptian children. In addition there was a synergism between GG genotype of CYP2R1 and CC genotype of CYP27B1 regarding the risk of development of type 1 diabetes. (c) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：42 / 45
页数：4
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