Novel 4-N-substituted aryl pent-2-ene-1,4-dione derivatives of piperazinyloxazolidinones as antibacterials

被引：24
|
作者：
Lohray, BB [1 ]
Lohray, VB [1 ]
Srivastava, BK [1 ]
Gupta, S [1 ]
Solanki, M [1 ]
Pandya, P [1 ]
Kapadnis, P [1 ]
机构：
[1] Zydus Res Ctr, Ahmadabad 382210, Gujarat, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 06期
关键词：
piperazinylaryloxazolidinone; in vitro MIC; linezolid; eperezolid; antibacterials; Gram-positive bacteria;
D O I：
10.1016/j.bmcl.2005.12.025
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A few substituted piperazinylphenyloxazolidinone compounds 6-13 having substitution on the distant nitrogen atom of piperazine ring scaffold have been synthesized and evaluated for their antibacterial activity in Gram-positive bacteria. A few compounds showed superior in vitro antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes than linezolid and eperezolid. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1557 / 1561
页数：5
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