Proton decoupled 19F NMR spectroscopy of drugs used in eye treatment

被引：1
|
作者：
Sæther, O
Midelfart, A
Risa, O
Haraldseth, O
Krane, J
机构：
[1] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway
[2] Norwegian Univ Sci & Technol, Dept Phys, N-7034 Trondheim, Norway
[3] Norwegian Univ Sci & Technol, Dept Ophthalmol, N-7034 Trondheim, Norway
[4] Norwegian Univ Sci & Technol, Dept Circulat & Med Imaging, N-7034 Trondheim, Norway
[5] Norwegian Univ Sci & Technol, Dept Chem, N-7034 Trondheim, Norway
[6] St Olavs Hosp, MR Ctr, Dept Med Imaging, N-7006 Trondheim, Norway
来源：
SPECTROSCOPY LETTERS | 2006年 / 39卷 / 02期
关键词：
fluorine; time-share; decoupling; ciprofloxacin; dexamethasone;
D O I：
10.1080/00387010500531084
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
The potential for detecting fluorinated compounds in a 2.35 T nuclear magnetic resonance system was assessed to evaluate the possibility for in vivo monitoring of fluorinated drugs applied to the eye. Time-share proton decoupled F-19 NMR spectroscopy was implemented for signal enhancement in an experimental eye model. Signal-to-noise in F-19 NMR spectra of dexamethasone phosphate was enhanced by 56%. However, decoupling did not enhance S/N for ciprofloxacin. The obtained detection limit of 0.1-0.2 mu mol did not enable detection of drugs at therapeutic concentrations in the eye. Higher magnetic field and improved coil and detection technology might enable future in vivo monitoring of drugs in the eye.
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页码：135 / 144
页数：10
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