Antiinflammatory and antiulcerogenic activities of Pistacia lentiscus L. leaves extracts

被引：26

作者：

Dellai, Afef ^{[1
]}

Souissi, Henda ^{[1
]}

Borgi, Wahida ^{[1
]}

Bouraoui, Abderrahman ^{[1
]}

Chouchane, Nabil ^{[1
]}

机构：

[1] Univ Monastir, Lab Pharmacol, Fac Pharm Monastir, Monastir 5000, Tunisia

来源：

INDUSTRIAL CROPS AND PRODUCTS | 2013年 / 49卷

关键词：

Pistacia lentiscus L; Anti-inflammatory activity; Antiulcerogenic activity; Leaves extracts; NATURAL-PRODUCTS; GASTRIC-LESIONS; CARRAGEENAN; APOPTOSIS; INDUCTION; PATHWAY;

D O I：

10.1016/j.indcrop.2013.07.010

中图分类号：

S2 [农业工程];

学科分类号：

0828 ;

摘要：

Plants have been used for centuries in traditional medicines. In the present study, we investigated in vivo the efficacy of the aqueous and organic extracts from Pistacia lentiscus L leaves for their anti-inflammatory and antiulcerogenic activities using the carrageenan-induced paw edema assay and HCl/ethanol-induced Gastric lesions in rats, respectively. The aqueous (AQ), chloroformic (CHCl3), ethyl acetate (EtOAc) and methanolic (MeOH) leaves extracts (50,100 and 200 mg/kg) given intraperitoneally (i.p.) showed a dose-dependent anti-inflammatory effect. The CHCl3, EtOAc and MeOH leaves extracts when administered orally (p.o), (25,50 and 100 mg/kg), exhibited an inhibition of gastric lesions in a concentration-related manner. The effect of all extracts in both activities were compared with reference drugs. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：879 / 882

页数：4

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