Innate immune activation in obesity

被引：108
|
作者：
Lumeng, Carey N. [1 ,2 ]
机构：
[1] Univ Michigan, Sch Med, Dept Pediat & Communicable Dis, Ann Arbor, MI USA
[2] Univ Michigan, Sch Med, Ann Arbor, MI USA
来源：
MOLECULAR ASPECTS OF MEDICINE | 2013年 / 34卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Obesity; Inflammation; Macrophages; Type; 2; diabetes; Insulin resistance; Metabolic syndrome; ADIPOSE-TISSUE MACROPHAGES; ACYLATION-STIMULATING PROTEIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INDUCED INSULIN-RESISTANCE; NECROSIS-FACTOR-ALPHA; TOLL-LIKE RECEPTOR-4; DIET-INDUCED OBESITY; KILLER T-CELLS; NF-KAPPA-B; METABOLIC SYNDROME;
D O I：
10.1016/j.mam.2012.10.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The innate immune system is a prewired set of cellular and humoral components that has developed to sense perturbations in normal physiology and trigger responses to restore the system back to baseline. It is now understood that many of these components can also sense the physiologic changes that occur with obesity and be activated. While the exact reasons for this chronic immune response to obesity are unclear, there is strong evidence to suggest that innate inflammatory systems link obesity and disease. Based on this, anti-inflammatory therapies for diseases like type 2 diabetes and metabolic syndrome may form the core of future treatment plans. This review will highlight the components involved in the innate immune response and discuss the evidence that they contribute to the pathogenesis of obesity-associated diseases. (C) 2012 Published by Elsevier Ltd.
引用
收藏
页码：12 / 29
页数：18
相关论文
共 50 条
  • [31] Activation of the innate immune system in atherosclerotic disease
    Oude Nijhuis, M. M.
    van Keulen, J. K.
    Pasterkamp, G.
    Quax, P. H.
    de Kleijn, D. P. V.
    CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (10) : 983 - 994
  • [32] A role for BLyS in the activation of innate immune cells
    Chang, Sock Kyung
    Arendt, Bonnie K.
    Darce, Jaime R.
    Wu, Xiaosheng
    Jelinek, Diane F.
    BLOOD, 2006, 108 (08) : 2687 - 2694
  • [33] Activation of innate immune receptors by bacterial products
    Brightbill, HD
    Modlin, RL
    MOLECULAR CELLULAR MICROBIOLOGY, 2002, 31 : 397 - 418
  • [34] Unintended consequences of innate immune activation by coronaviruses
    Plonski, Noel-Marie
    Nitirahardjo, Caroline
    Meindl, Richard
    Piontkivska, Helen
    FASEB JOURNAL, 2021, 35
  • [35] Effect of alginate on innate immune activation of macrophages
    Yang, Dong
    Jones, Kim S.
    JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2009, 90A (02) : 411 - 418
  • [36] Activation of the innate immune response by endogenous retroviruses
    Hurst, Tara P.
    Magiorkinis, Gkikas
    JOURNAL OF GENERAL VIROLOGY, 2015, 96 : 1207 - 1218
  • [37] Periodontal innate immune mechanisms relevant to atherosclerosis and obesity
    Zelkha, Sami A.
    Freilich, Robert W.
    Amar, Salomon
    PERIODONTOLOGY 2000, 2010, 54 : 207 - 221
  • [38] Innate immune activation in neutrophilic asthma and bronchiectasis
    Simpson, Jodie L.
    Grissell, Terry V.
    Douwes, Jeroen
    Scott, Rodney J.
    Boyle, Michael J.
    Gibson, Peter G.
    THORAX, 2007, 62 (03) : 211 - 218
  • [39] Innate immune receptors drive dengue virus immune activation and disease
    Sprokholt, Joris
    Helgers, Leanne C.
    Geijtenbeek, Teunis B. H.
    FUTURE VIROLOGY, 2018, 13 (04) : 287 - 305
  • [40] Editorial: NLRP3 activation and regulation in innate immune responses NLRP3 activation and regulation in innate immune responses
    Mortellaro, Alessandra
    FRONTIERS IN IMMUNOLOGY, 2023, 14
12345