Improvement on analyte extraction by molecularly imprinted polymer microspheres toward enrofloxacin

A collection of molecularly imprinted polymer microspheres (MIPMs) for Enrofloxacin (ENRO) were for the first time obtained through suspension polymerization in this work. The appropriate MIPMs used as specific SPE adsorbents were selected based on evaluation of binding capacities and morphology characterization. Combined with one simpler MISPE procedure for cleanup and preconcentration of ENRO in milk, further HPLC-UV analysis showed improved sensitivity of 10 mu g kg(-1) than those reported in previous studies, with the desirable recoveries of 73.6-101.6%, proving that the developed MIPMs are applicable for extraction of ENRO during the process of sample preparation.