TRP Channels

被引：129
|
作者：
Gees, Maarten [1 ,2 ]
Owsianik, Grzegorz [1 ,2 ]
Nilius, Bernd [1 ,2 ]
Voets, Thomas [1 ,2 ]
机构：
[1] Katholieke Univ Leuven, Lab Ion Channel Res, Louvain, Belgium
[2] Katholieke Univ Leuven, TRP Res Platform Leuven TRPLe, Louvain, Belgium
来源：
COMPREHENSIVE PHYSIOLOGY | 2012年 / 2卷 / 01期
关键词：
NONSELECTIVE CATION CHANNEL; POLYCYSTIC KIDNEY-DISEASE; EPITHELIAL CA2+ CHANNELS; RECEPTOR POTENTIAL CHANNELS; MUCOLIPIDOSIS TYPE-IV; INTEGRAL MEMBRANE-PROTEIN; MOUSE TRANSIENT RECEPTOR; ARTERIAL SMOOTH-MUSCLE; HEAT-EVOKED ACTIVATION; CALCIUM-ENTRY CHANNEL;
D O I：
10.1002/cphy.c110026
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential (trp) locus in Drosophila. In mammals, 28 different TRP channel genes have been identified, which exhibit a large variety of functional properties and play diverse cellular and physiological roles. In this article, we provide a brief and systematic summary of expression, function, and (patho)physiological role of the mammalian TRP channels. (C) 2012 American Physiological Society. Compr Physiol 2: 563-608, 2012.
引用
收藏
页码：563 / 608
页数：46
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