Secondary metabolites from the root of Ehretia longiflora and their biological activities

被引：22

作者：

Chien, Yu-Chieh ^{[1
]}

Lin, Chu-Hung ^{[2
]}

Chiang, Michael Y. ^{[3
]}

Chang, Hsun-Shuo ^{[1
]}

Liao, Chang-Hui ^{[4
]}

Chen, Ih-Sheng ^{[1
,2
]}

Peng, Chien-Fang ^{[5
]}

Tsai, Ian-Lih ^{[1
,2
]}

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Kaohsiung Med Univ, Coll Pharm, Sch Pharm, Kaohsiung 807, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 804, Taiwan

[4] Chang Gung Univ, Coll Med, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[5] Kaohsiung Med Univ, Coll Hlth Sci, Dept Med Lab Sci & Biotechnol, Kaohsiung 807, Taiwan

来源：

PHYTOCHEMISTRY | 2012年 / 80卷

关键词：

Ehretia longiflora; Boraginaceae; Root; Antitubercular activity; Anti-inflammatory activity; ACID; GRANULOCYTES; CONSTITUENTS; GLUCOSIDES; LEUKOCYTES; COMPOUND; BLOOD; CELLS;

D O I：

10.1016/j.phytochem.2012.04.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bioassay-guided fractionation of the methanolic extract of the root of Ehretia longiflora (Boraginaceae) afforded eight compounds. ehretiquinone (1), ehretiolide (2), ehreticoumarin (3), ehretilactone A (4), ehretilactone B (5), ehretiamide (6), ehretine (7), and ehretiate (8), together with 12 known compounds (9-20). The relative configuration of 1 was determined by single crystal X-ray diffraction. Among the isolates, 1 and prenylhydroquinone (14) showed antitubercular activity against Mycobacterium tuberculosis strain H37Rv with MIC values of 25.0 and 26.2 mu g/mL, respectively. Moreover, 1 exhibited inhibitory effects on N-formylmethionylleucylphenylalanine (fMLP)-induced superoxide production, with IC50 value of 0.36 +/- 0.03 mu M. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：50 / 57

页数：8

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