Memory Consolidation Is Linked to Spindle-Mediated Information Processing during Sleep

被引:169
|
作者
Cairney, Scott A. [1 ]
Guttesen, Anna A. Vali [1 ]
El Marj, Nicole [2 ]
Staresina, Bernhard P. [2 ]
机构
[1] Univ York, Dept Psychol, York Y010 5DD, N Yorkshire, England
[2] Univ Birmingham, Sch Psychol, Birmingham B15 2TT, W Midlands, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
CLOSED-LOOP STIMULATION; SLOW OSCILLATIONS; REACTIVATION; TERM; HIPPOCAMPUS; RESPONSES; RIPPLES;
D O I
10.1016/j.cub.2018.01.087
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
How are brief encounters transformed into lasting memories? Previous research has established the role of non-rapid eye movement (NREM) sleep, along with its electrophysiological signatures of slow oscillations (SOs) and spindles, for memory consolidation [1-4]. In related work, experimental manipulations have demonstrated that NREM sleep provides a window of opportunity to selectively strengthen particular memory traces via the delivery of auditory cues [5-10], a procedure known as targeted memory reactivation (TMR). It has remained unclear, however, whether TMR triggers the brain's endogenous consolidation mechanisms (linked to SOs and/or spindles) and whether those mechanisms in turn mediate effective processing of mnemonic information. We devised a novel paradigm in which associative memories (adjective-object and adjective-scene pairs) were selectively cued during a post-learning nap, successfully stabilizing next-day retention relative to non-cued memories. First, we found that, compared to novel control adjectives, memory cues evoked an increase in fast spindles. Critically, during the time window of cue-induced spindle activity, the memory category linked to the verbal cue (object or scene) could be reliably decoded, with the fidelity of this decoding predicting the behavioral consolidation benefits of TMR. These results provide correlative evidence for an information processing role of sleep spindles in service of memory consolidation.
引用
收藏
页码:948 / +
页数:11
相关论文
共 50 条
  • [41] Contribution of norepinephrine to emotional memory consolidation during sleep
    Groch, Sabine
    Wilhelm, Ines
    Diekelmann, Susanne
    Sayk, Friedhelm
    Gais, Steffen
    Born, Jan
    PSYCHONEUROENDOCRINOLOGY, 2011, 36 (09) : 1342 - 1350
  • [42] Sculpting memory during sleep: concurrent consolidation and forgetting
    Feld, Gordon B.
    Born, Jan
    CURRENT OPINION IN NEUROBIOLOGY, 2017, 44 : 20 - 27
  • [43] Impaired memory consolidation during sleep in patients with obstructive sleep apnea
    Kloepfer, C.
    Nissen, C.
    Feige, B.
    Sorichter, S.
    Riemann, D.
    JOURNAL OF SLEEP RESEARCH, 2008, 17 : 150 - 151
  • [44] Impaired memory consolidation during sleep in primary insomnia
    Nissen, C.
    Kloepfer, C.
    Feige, B.
    Riemann, D.
    SLEEP, 2008, 31 : A227 - A227
  • [45] Metabolic fingerprints of fear memory consolidation during sleep
    Iyo Koyanagi
    Kazuhiro Sonomura
    Toshie Naoi
    Takaaki Ohnishi
    Naoko Kaneko
    Kazunobu Sawamoto
    Taka-Aki Sato
    Masanori Sakaguchi
    Molecular Brain, 14
  • [46] Memory consolidation during sleep and adult hippocampal neurogenesis
    Iyo Koyanagi
    Katherine G.Akers
    Pablo Vergara
    Sakthivel Srinivasan
    Takeshi Sakurai
    Masanori Sakaguchi
    NeuralRegenerationResearch, 2019, 14 (01) : 20 - 23
  • [47] Memory consolidation during sleep: A form of brain restitution
    Sheth, BR
    BEHAVIORAL AND BRAIN SCIENCES, 2005, 28 (01) : 81 - +
  • [48] Memory consolidation during sleep and adult hippocampal neurogenesis
    Koyanagi, Iyo
    Akers, Katherine G.
    Vergara, Pablo
    Srinivasan, Sakthivel
    Sakurai, Takeshi
    Sakaguchi, Masanori
    NEURAL REGENERATION RESEARCH, 2019, 14 (01) : 20 - 23
  • [49] Competitive learning modulates memory consolidation during sleep
    Antony, James W.
    Cheng, Larry Y.
    Brooks, Paula P.
    Paller, Ken A.
    Norman, Kenneth A.
    NEUROBIOLOGY OF LEARNING AND MEMORY, 2018, 155 : 216 - 230
  • [50] Impaired memory consolidation during sleep in patients with obstructive sleep apnea
    Kloepfer, C.
    Nissen, C.
    Feige, B.
    Riemann, D.
    SLEEP, 2008, 31 : A377 - A377