PRECLINICAL ANTITUMOR ACTIVITY OF THIARABINE IN HUMAN LEUKEMIA AND LYMPHOMA XENOGRAFT MODELS

被引：3
|
作者：
Waud, William R. [1 ]
Gilbert, Karen S. [1 ]
Secrist, John A., III [1 ]
机构：
[1] So Res Inst, Canc Therapeut & Immunol Dept, Birmingham, AL 35255 USA
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2012年 / 31卷 / 09期
关键词：
Thiarabine; leukemia; lymphoma; ara-C; clofarabine; fludarabine monophosphate; cladribine; gemcitabine; 4'-THIO-BETA-D-ARABINOFURANOSYLCYTOSINE 4'-THIO-ARA-C; GEMCITABINE; P388;
D O I：
10.1080/15257770.2012.710768
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thiarabine was evaluated for antitumor activity in seven human leukemia, lymphoma, and myeloma xenograft models to explore the activity in hematological malignancies. Thiarabine was active against all of the human leukemia and lymphoma lines tested, being curative against HL-60 leukemia and AS283 lymphoma and effecting tumor regressions in CCRF-CEM, MOLT-4, and K-562 leukemia and RL lymphoma models, but did not exhibit any appreciable activity against RPMI-8226 myeloma. For the leukemia/lymphoma models, thiarabine was more efficacious than ara-C/palmO-ara-C (four models), clofarabine (three models), fludarabine monophosphate (five models), cladribine (four models), and gemcitabine (six models). Thiarabine warrants future clinical trials with leukemias/lymphomas.
引用
收藏
页码：647 / 660
页数：14
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