Functional selectivity of GPCR signaling in animals

被引：43
|
作者：
Zhou, Lei [1 ,2 ]
Bohn, Laura M. [1 ,2 ]
机构：
[1] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USA
[2] Scripps Res Inst, Dept Neurosci, Jupiter, FL 33458 USA
来源：
CURRENT OPINION IN CELL BIOLOGY | 2014年 / 27卷
关键词：
MU-OPIOID RECEPTOR; PARATHYROID-HORMONE RECEPTOR; AMINE-ASSOCIATED RECEPTOR; G-PROTEIN; IN-VIVO; ARRESTIN INTERACTIONS; BIASED AGONISM; NICOTINIC-ACID; KNOCKOUT MICE; PHOSPHORYLATION;
D O I：
10.1016/j.ceb.2013.11.010
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
At one time, G protein-coupled receptors were envisioned to simply relay either inhibitory or stimulatory binary signals through engaging particular G proteins. These receptors are now viewed as complex, multidimensional triggers of a variety of potential signaling cascades. This review will showcase current attempts to elucidate biased signaling and functional selectivity in tissues and organs as well as in the whole animal. In addition, it will emphasize the challenges that are inherent in attributing bias in a living system as well as offer opinions as to the manner in which these problems may be approached.
引用
收藏
页码：102 / 108
页数：7
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