A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance

被引：2

作者：

Wozniak, Jessie E. ^{[1
,2
,3
,4
]}

Band, Victor I. ^{[1
,2
,3
,4
]}

Conley, Andrew B. ^{[6
]}

Rishishwar, Lavanya ^{[6
]}

Burd, Eileen M. ^{[3
,4
]}

Satola, Sarah W. ^{[3
,4
]}

Hardy, Dwight J. ^{[8
]}

Tsay, Rebecca ^{[8
]}

Farley, Monica M. ^{[3
,4
,5
]}

Jacob, Jesse T. ^{[3
,4
]}

Dumyati, Ghinwa ^{[8
]}

Jordan, I. King ^{[6
,7
]}

Weiss, David S. ^{[2
,3
,4
,5
]}

机构：

[1] Emory Univ, Atlanta, GA 30322 USA

[2] Emory Vaccine Ctr, Atlanta, GA 30317 USA

[3] Emory Univ, Sch Med, Atlanta, GA 30322 USA

[4] Emory Antibiot Resistance Ctr, Atlanta, GA 30322 USA

[5] Atlanta VA Med Ctr, Decatur, GA 30033 USA

[6] Georgia Inst Technol, IHRC Appl Bioinformat Lab, Atlanta, GA 30332 USA

[7] Georgia Inst Technol, Sch Biol Sci, Atlanta, GA 30332 USA

[8] Univ Rochester, Med Ctr, Rochester, NY 14642 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 05期

关键词：

KPC; Klebsiella; colistin; heteroresistance; hypermucoviscous; LIVER-ABSCESSES; EMERGENCE;

D O I：

10.1128/AAC.00107-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The convergence of hypervirulence and multidrug resistance in Klebsiella pneumoniae is a significant concern. Here, we report the first screen for hypermucoviscosity, a trait associated with increased virulence, using a U.S. surveillance collection of carbapenem- resistant (CR) K. pneumoniae isolates. We identified one hypermucoviscous isolate, which carried a gene encoding the KPC-3 carbapenemase, among numerous resistance genes. The strain further exhibited colistin heteroresistance undetected by diagnostics. This convergence of diverse resistance mechanisms and increased virulence underscores the need for enhanced K. pneumoniae surveillance.

引用

页数：4

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