Nocardiopsins C and D and nocardiopyrone A: new polyketides from an Australian marine-derived Nocardiopsis sp.

被引：19
|
作者：
Raju, Ritesh [1 ]
Piggott, Andrew M. [1 ]
Quezada, Michelle [1 ]
Capon, Robert J. [1 ]
机构：
[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
来源：
TETRAHEDRON | 2013年 / 69卷 / 02期
基金：
澳大利亚研究理事会;
关键词：
Nocardiopsis; Marine-derived actinomycetes; Prolinyl-macrolactam polyketides; alpha-Pyrone polyketides; Microbial natural products chemistry; RAPAMYCIN ANALOGS; STARTER UNIT; ACTINOMYCETE; SYNTHASE; GERMICIDIN; ACP;
D O I：
10.1016/j.tet.2012.10.104
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Nocardiopsis sp. (CMB-M0232) recovered from marine sediment collected off the coast of South Molle Island, Queensland, Australia, yielded two new examples of rare prolinyl-macrolactam polyketides, nocardiopsins C (1) and D (2), a new highly substituted alpha-pyrone polyketide, nocardiopyrone A (3), and the previously reported macrolide polyketides nocardiopsins A (4) and B (5). Structures were assigned on the basis of detailed spectroscopic analysis, degradation, and chemical derivatization. PCR amplification of CMB-M0232 genomic DNA revealed the presence of type I and type II polyketide synthase and non-ribosomal peptide synthase domains. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：692 / 698
页数：7
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