Nocardiopsins C and D and nocardiopyrone A: new polyketides from an Australian marine-derived Nocardiopsis sp.

被引：19
|
作者：
Raju, Ritesh [1 ]
Piggott, Andrew M. [1 ]
Quezada, Michelle [1 ]
Capon, Robert J. [1 ]
机构：
[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia
来源：
TETRAHEDRON | 2013年 / 69卷 / 02期
基金：
澳大利亚研究理事会;
关键词：
Nocardiopsis; Marine-derived actinomycetes; Prolinyl-macrolactam polyketides; alpha-Pyrone polyketides; Microbial natural products chemistry; RAPAMYCIN ANALOGS; STARTER UNIT; ACTINOMYCETE; SYNTHASE; GERMICIDIN; ACP;
D O I：
10.1016/j.tet.2012.10.104
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Nocardiopsis sp. (CMB-M0232) recovered from marine sediment collected off the coast of South Molle Island, Queensland, Australia, yielded two new examples of rare prolinyl-macrolactam polyketides, nocardiopsins C (1) and D (2), a new highly substituted alpha-pyrone polyketide, nocardiopyrone A (3), and the previously reported macrolide polyketides nocardiopsins A (4) and B (5). Structures were assigned on the basis of detailed spectroscopic analysis, degradation, and chemical derivatization. PCR amplification of CMB-M0232 genomic DNA revealed the presence of type I and type II polyketide synthase and non-ribosomal peptide synthase domains. (c) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：692 / 698
页数：7
相关论文
共 50 条
  • [1] Nocardiopsins: New FKBP12-Binding Macrolide Polyketides from an Australian Marine-Derived Actinomycete, Nocardiopsis sp.
    Raju, Ritesh
    Piggott, Andrew M.
    Conte, Melissa
    Tnimov, Zakir
    Alexandrov, Kirill
    Capon, Robert J.
    CHEMISTRY-A EUROPEAN JOURNAL, 2010, 16 (10) : 3194 - 3200
  • [2] Nocapyrones: α-and γ-Pyrones from a Marine-Derived Nocardiopsis sp.
    Kim, Youngju
    Ogura, Hiromu
    Akasaka, Kazuaki
    Oikawa, Tsutomu
    Matsuura, Nobuyasu
    Imada, Chiaki
    Yasuda, Hisato
    Igarashi, Yasuhiro
    MARINE DRUGS, 2014, 12 (07) : 4110 - 4125
  • [3] Polyketides from a Marine-Derived Fungus Xylariaceae sp.
    Nong, Xu-Hua
    Zheng, Zhi-Hui
    Zhang, Xiao-Yong
    Lu, Xin-Hua
    Qi, Shu-Hua
    MARINE DRUGS, 2013, 11 (05): : 1718 - 1727
  • [4] Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived Nocardiopsis sp.
    Kim, Min Cheol
    Hwang, Eunson
    Kim, Taejung
    Ham, Jungyeob
    Kim, Sun Yeou
    Kwon, Hak Cheol
    JOURNAL OF NATURAL PRODUCTS, 2014, 77 (10): : 2326 - 2330
  • [5] Five polyketides isolated from the marine-derived fungus Arthrinium Sp.
    Zhao, Zhaihai
    Ding, Wanjing
    Wang, Pin-Mei
    Zheng, Daoqiong
    Xu, Jinzhong
    NATURAL PRODUCT RESEARCH, 2021, 35 (15) : 2470 - 2475
  • [6] Heronamycin A: a new benzothiazine ansamycin from an Australian marine-derived Streptomyces sp.
    Raju, Ritesh
    Piggott, Andrew M.
    Khalil, Zeinab
    Bernhardt, Paul V.
    Capon, Robert J.
    TETRAHEDRON LETTERS, 2012, 53 (09) : 1063 - 1065
  • [7] Pteridic acids C–G spirocyclic polyketides from the marine-derived Streptomyces sp. SCSGAA 0027
    Xu-Hua Nong
    Xiao-Yi Wei
    Shu-Hua Qi
    The Journal of Antibiotics, 2017, 70 : 1047 - 1052
  • [8] New and bioactive polyketides from Hawaiian marine-derived fungus Trichoderma sp. FM652
    Zaman, Kh Ahammad Uz
    Wu, Xiaohua
    Sarotti, Ariel M.
    Cao, Shugeng
    NATURAL PRODUCT RESEARCH, 2022, 36 (23) : 5984 - 5990
  • [9] New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2
    Xu, Yan
    Huang, Ruibao
    Liu, Hongwei
    Yan, Tingting
    Ding, Wanjing
    Jiang, Yongjun
    Wang, Pinmei
    Zheng, Daoqiong
    Xu, Jinzhong
    MARINE DRUGS, 2020, 18 (01)
  • [10] Acremolides A-D, lipodepsipeptides from an Australian marine-derived fungus, Acremonium sp.
    Ratnayake, Ranjala
    Fremlin, Leith J.
    Lacey, Ernest
    Gill, Jennifer H.
    Capon, Robert J.
    JOURNAL OF NATURAL PRODUCTS, 2008, 71 (03): : 403 - 408
12345