GENETIC VARIABILITY OF BOLA-DRB3.2 GENE IN KENKATHA BREED OF CATTLE ASSESSED BY PCR-SSCP

被引：0
|
作者：
Ranjan, Rakesh [1 ]
Bhong, C. D. [1 ]
Chavan, K. N. [1 ]
Parmar, S. N. S. [1 ]
Joshi, C. G. [1 ]
机构：
[1] MPPCVV, Anim Biotechnol Ctr, Jabalpur 482004, India
来源：
INDIAN JOURNAL OF ANIMAL RESEARCH | 2013年 / 47卷 / 02期
关键词：
BoLA; Kenkatha; PCR; -SSCP; MHC;
D O I：
暂无
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Present study was conducted to investigate BOLA (Bovine leucocyte antigen) gene polymorphism in indigenous draft Kenkatha (n=52) breed of cattle at DRB3.2 loci by PCR-SSCP (Single strand conformational polymorphism). This BoLA region encodes cell surface glycoprotein, which binds to foreign antigens of T lymphocytes that play central role in the induction and regulation of adaptive immunity. A PCR-SSCP of 284bp amplicon of BoLA-DRB3.2 gene revealed 13 SSCP patterns. This suggests that exon 2 region of BoLA-DRB3 is highly polymorphic in nature. This may be due to natural selection on a BoLA allele pool, leading to the development of resistance to local infectious diseases.
引用
收藏
页码：164 / 167
页数：4
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