Indirect stimulatory effects of murine interleukin-12 on in vitro production of nitric oxide by mouse peritoneal cells

被引：3
|
作者：
Zidek, Z
Lotzova, E
Frankova, D
Savary, CA
机构：
[1] UNIV TEXAS, MD ANDERSON CANC CTR, DEPT SURG ONCOL, HOUSTON, TX 77030 USA
[2] ACAD SCI CZECH REPUBL, INST PHARMACOL, PRAGUE, CZECH REPUBLIC
来源：
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1996年 / 16卷 / 05期
关键词：
D O I：
10.1089/jir.1996.16.389
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of murine interleukin-12 (IL-12) on L-arginine-dependent biosynthesis of nitric oxide (NO) by mouse peritoneal cells was evaluated. Interleukin-12 was found to trigger considerably enhanced production of NO in a dose-dependent manner. Antibody neutralization studies indicated that the effect of IL-12 was mediated by IFN-gamma without apparent participation of TNF-alpha. Synergistic effects of IL-12 plus lipopolysaccharide (LPS) were also observed. Our data thus provide evidence that IL-12 is a powerful but indirect modulator of NO formation. These findings may contribute to the better understanding of various biologic effects of IL-12.
引用
收藏
页码：389 / 393
页数：5
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