Silver-catalyzed multicomponent reactions for the construction of γ-carbonyl-α-amino acid derivatives

被引：7

作者：

Yuan, Chunming ^{[1
]}

Zhao, Xiaohui ^{[2
,3
]}

Nan, Guangming ^{[1
]}

机构：

[1] Yili Normal Univ, Univ & Coll Key Lab Nat Prod Chem & Applicat Xinj, Sch Chem & Environm Sci, Yining 835000, Peoples R China

[2] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

[3] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 39期

关键词：

Silver-catalyzed; gamma-carbonyl-alpha-amino acid derivatives; Multicomponent reaction; A3-coupling; ONE-POT SYNTHESIS; COOPERATIVE CATALYSIS; EFFICIENT SYNTHESIS; CONJUGATE ADDITION; SECONDARY AMINE; MANNICH; INHIBITOR; ALDEHYDES; MICHAEL; ALKYNES;

D O I：

10.1016/j.tetlet.2020.152318

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Silver-catalyzed multicomponent strategy for the construction of highly functionalized gamma-carbonyl-alpha-camino acid derivatives has been developed under mild conditions, in which various gamma-carbonyl-alpha-amino acid derivatives were obtained in moderate to excellent yields. Preliminary mechanistic studies suggested that silver-catalyzed A(3)-coupling reaction and alkyne hydration process were accomplished in a simple operation. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：4

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