Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of Cardiac Troponin I and the Drug W7: The Basis of W7 as an Inhibitor of Cardiac Muscle Contraction

被引:1
|
作者
Oleszczuk, Marta [1 ]
Robertson, Ian M. [1 ]
Li, Monica X. [1 ]
Sykes, Brian D. [1 ]
机构
[1] Univ Alberta, Edmonton, AB, Canada
关键词
D O I
10.1016/j.bpj.2009.12.806
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:150A / 150A
页数:1
相关论文
共 32 条
  • [11] Effect of W7 inhibition on the sarcomere length dependence of cardiac muscle activation
    Adhikari, BB
    Martyn, D
    Regnier, M
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 209A - 209A
  • [12] Interplay of troponin- and myosin-based pathways of calcium activation in skeletal and cardiac muscle: The use of W7 as an inhibitor of thin filament activation
    Adhikari, BB
    Wang, K
    BIOPHYSICAL JOURNAL, 2004, 86 (01) : 359 - 370
  • [13] Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil
    Wang, X
    Li, MX
    Sykes, BD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (34) : 31124 - 31133
  • [14] Regulatory domain conformational exchange and linker region flexibility in cardiac troponin C bound to cardiac troponin I
    Abbott, MB
    Gaponenko, V
    Abusamhadneh, E
    Finley, N
    Li, G
    Dvoretsky, A
    Rance, M
    Solaro, RJ
    Rosevear, PR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (27) : 20610 - 20617
  • [15] Interplay of troponin- and myosin-based pathways of calcium activation in skeletal and cardiac muscle: The use of W7 and BDM as specific inhibitors
    Adhikari, BB
    Wang, K
    BIOPHYSICAL JOURNAL, 2003, 84 (02) : 569A - 569A
  • [16] Structure of the n-domain of cardiac troponin C in complex with bepridil and cardiac troponin-I147-163.
    Li, MX
    Wang, X
    Spyracopoulos, L
    Sykes, BD
    BIOPHYSICAL JOURNAL, 2001, 80 (01) : 88A - 88A
  • [17] Interaction of human cardiac Troponin-I (residues 148-164) with the regulatory domain of human cardiac Troponin-C.
    Li, MX
    Spyracopoulos, L
    Sykes, BD
    BIOPHYSICAL JOURNAL, 1998, 74 (02) : A51 - A51
  • [18] Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain
    Sia, SK
    Li, MX
    Spyracopoulos, L
    Gagne, SM
    Liu, W
    Putkey, JA
    Sykes, BD
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (29) : 18216 - 18221
  • [19] Comparison of the Binding of the Switch Regions of Cardiac Troponin-I and Skeletal Troponin-I to the Functional N-Domain of Human Cardiac Troponin-C
    Holmes, Peter C.
    Robertson, Ian M.
    Li, Monica X.
    Sykes, Brian D.
    BIOPHYSICAL JOURNAL, 2010, 98 (03) : 147A - 148A
  • [20] The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C
    Hwang, Peter M.
    Cai, Fangze
    Pineda-Sanabria, Sandra E.
    Corson, David C.
    Sykes, Brian D.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (40) : 14412 - 14417