Synthesis of cinacalcet hydrochloride under solvent-free conditions

被引：0
|
作者：
Chavakula, Ramadas [1 ]
Mutyala, Narayana Rao [1 ]
Chennupati, Srinivasa Rao [1 ]
机构：
[1] Tyche Ind Ltd, Hyderabad 500093, Andhra Pradesh, India
来源：
JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2013年 / 90卷 / 12期
关键词：
Calcimimetics; cinacalcet; reductive amination; solvent-free reaction; sodium borohydride; boric acid;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and convenient procedure for synthesis of cinacalcet hydrochloride by reductive amination of (R)-(1-naphthyl)ethylamine and 3[3-(trifluoromethyl)phenyl]propionaldehyde using sodium borohydride activated by boric acid, p-toluenesulfonic acid monohydrate or benzoic acid as reducing agent under solvent-free conditions is described.
引用
收藏
页码：2291 / 2292
页数：2
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