Down-regulated Expression of ATG5 in Colorectal Cancer

被引：4
|
作者：
Cho, Dong-Hyung [1 ]
Jo, Yoon Kyung [1 ,2 ]
Kim, Seung Cheol [2 ,3 ]
Park, In Ja [3 ]
Kim, Jin Cheon [2 ,3 ]
机构：
[1] Kyung Hee Univ, Grad Sch EW Med Sci, Yongin 446701, Gyeonggi Do, South Korea
[2] Asan Med Ctr, Inst Innovat Canc Res, Seoul, South Korea
[3] Univ Ulsan, Coll Med, Dept Surg, Seoul, South Korea
来源：
ANTICANCER RESEARCH | 2012年 / 32卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
ATG5; autophagy; colorectal cancer; tumor suppressor; LVI; AUTOPHAGY; GENE; TUMORIGENESIS; DEFICIENT; ROLES;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The role of autophagy in tumor development is paradoxical. Although some genetic evidence has indicated that autophagy has as a tumor suppressor function, it also provides some advantages to tumors under metabolic stress conditions. Autophagy is regulated by several autophagy-related gene (ATG) proteins. In mammals, 16 different ATG genes have been identified. To investigate the clinicopathological role of ATG5 in colorectal cancer, we firstly investigated its expression in patients with sporadic colorectal cancer. Expression analysis revealed ATG5 to be strongly down-regulated in colorectal cancer (38140 patients). Interestingly, immunohistochemical analysis of colorectal cancer tissues indicated that increased ATG5 expression is associated with lymphovascular invasion (p=0.035). The findings in our limited clinical cohort indicate that ATG5 could be a potential prognostic or diagnostic biomarker.
引用
收藏
页码：4091 / 4096
页数：6
相关论文
共 50 条
  • [31] Alteration of Autophagy-Related Protein 5 (ATG5) Levels and Atg5 Gene Expression in Diabetes Mellitus with and Without Complications
    Nakhoul, Farid M.
    Nakhoul, Nakhoul
    Farber, Evgeny
    Nakhoul-Armaly, Aida
    Tadmor, Hagar
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (10): : 246 - 246
  • [32] HIF1α promotes prostate cancer progression by increasing ATG5 expression
    Yu, Kaiyuan
    Xiang, Luxia
    Li, Shaoxun
    Wang, Shuaibin
    Chen, Chaohao
    Mu, Haiqi
    ANIMAL CELLS AND SYSTEMS, 2019, 23 (05) : 326 - 334
  • [33] Exon Sequence Analysis of the ATG5, ATG12, ATG9B Genes in Colorectal Cancer Patients During Radiotherapy
    Gurbuz, Tugba Mehmetoglu
    Oral, Ethem Nezih
    Sakin, Rabia Nergiz Dagoglu
    Karaman, Sule
    Durak, Sermin
    Sezgin, Saadet Buesra Aksoyer
    Keskin, Metin
    Celik, Faruk
    Zeybek, S. Umit
    INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY, 2025, 40 (02) : 263 - 273
  • [34] Intestinal mucosal CCR5 expression is down-regulated in HIV infection
    McGowan, I
    Elliott, J
    Taing, P
    Fuerst, M
    Boscardin, J
    Anton, P
    GASTROENTEROLOGY, 2003, 124 (04) : A155 - A155
  • [35] Two novel mucin genes down-regulated in colorectal cancer identified by differential display
    Williams, SJ
    McGuckin, MA
    Gotley, DC
    Eyre, HJ
    Sutherland, GR
    Antalis, TM
    CANCER RESEARCH, 1999, 59 (16) : 4083 - 4089
  • [36] ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor
    Li, Lin
    Yuan, Shiyun
    Zhao, Xunping
    Luo, Tao
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 524 (03) : 663 - 671
  • [37] Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells
    Baehs, Sebastian
    Herbst, Andreas
    Thieme, Susanne E.
    Perschl, Claudia
    Behrens, Andrea
    Scheel, Silvio
    Jung, Andreas
    Brabletz, Thomas
    Goeke, Burkhard
    Blum, Helmut
    Kolligs, Frank T.
    CANCER LETTERS, 2009, 276 (02) : 152 - 159
  • [38] Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis
    Alirezaei, Mehrdad
    Fox, Howard S.
    Flynn, Claudia T.
    Moore, Craig S.
    Hebb, Andrea L. O.
    Frausto, Ricardo F.
    Bhan, Virender
    Kiosses, William B.
    Whitton, J. Lindsay
    Robertson, George S.
    Crocker, Stephen J.
    AUTOPHAGY, 2009, 5 (02) : 152 - 158
  • [39] Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer
    Rechreche, H
    Mallo, GV
    Montalto, G
    Dagorn, JC
    Iovanna, JL
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1997, 248 (01): : 225 - 230
  • [40] Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer
    Woelfle, U
    Sauter, G
    Santjer, S
    Brakenhoff, R
    Pantel, K
    CLINICAL CANCER RESEARCH, 2004, 10 (08) : 2670 - 2674
12345