Multifunctional roles of insulin-like growth factor binding protein 5 in breast cancer

被引：57

作者：

Akkiprik, Mustafa ^{[2
]}

Feng, Yumei ^{[3
,4
]}

Wang, Huamin ^{[1
]}

Chen, Kexin ^{[5
]}

Hu, Limei ^{[1
]}

Sahin, Aysegul ^{[1
]}

Krishnamurthy, Savitri ^{[1
]}

Ozer, Ayse ^{[2
]}

Hao, Xishan ^{[3
,4
,5
]}

Zhang, Wei ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Unit 85, Houston, TX 77030 USA

[2] Marmara Univ, Sch Med, Dept Med Biol, TR-34668 Istanbul, Turkey

[3] Tianjin Med Univ, Canc Inst & Hosp, Dept Biochem & Mol Biol, Tianjin 300060, Peoples R China

[4] Tianjin Med Univ, Canc Inst & Hosp, Minist Educ, Breast Canc Prevent & Treatment Key Lab, Tianjin 300060, Peoples R China

[5] Tianjin Med Univ, Canc Inst & Hosp, Dept Epidemiol & Biostat, Tianjin 300060, Peoples R China

来源：

BREAST CANCER RESEARCH | 2008年 / 10卷 / 04期

关键词：

D O I：

10.1186/bcr2116

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The insulin-like growth factor axis, which has been shown to protect cells from apoptosis, plays an essential role in normal cell physiology and in cancer development. The family of insulin-like growth factor binding proteins (IGFBPs) has been shown to have a diverse spectrum of functions in cell growth, death, motility, and tissue remodeling. Among the six IGFBP family members, IGFBP-5 has recently been shown to play an important role in the biology of breast cancer, especially in breast cancer metastasis; however, the exact mechanisms of action remain obscure and sometimes paradoxical. An in-depth understanding of IGFBP-5 would shed light on its potential role as a target for breast cancer therapeutics.

引用

页数：14

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