7% Hypertonic saline in acute bronchiolitis: A Randomized Controlled Trial

This randomized controlled trial compared 7% hypertonic saline versus 0.9% (normal) saline, in addition to racemic epinephrine (in both groups), among infants with mild to moderate severity bronchiolitis. The authors used a modification of the oft-applied bronchiolitis severity score (BSS) by Wang, et al. [1] to evaluate the efficacy of treatment at multiple time points until discharge/ disposition from the hospital. They reported no statistically significant differences between the groups for changes in modified-BSS after 1 dose of treatment as well as until final disposition from the hospita.