Altered motion repulsion in Alzheimer's disease

被引:3
|
作者
Li, Yan [1 ]
Guo, Shougang [2 ]
Wang, Yongxiang [2 ]
Chen, Huan [3 ]
机构
[1] Zhengzhou Univ, Dept Neurol, Luoyang Cent Hosp, Luoyang City 471000, Peoples R China
[2] Shandong Univ, Dept Neurol, Shandong Prov Hosp, Jinan 250021, Peoples R China
[3] First Peoples Hosp Jinan City, Dept Neurol, Jinan 250011, Shandong, Peoples R China
来源
SCIENTIFIC REPORTS | 2017年 / 7卷
基金
中国国家自然科学基金;
关键词
VISUAL-MOTION; SPATIAL DISORIENTATION; COGNITIVE IMPAIRMENT; DIRECTION REPULSION; PERCEPTION; DYSFUNCTION; DEFICITS; INTEGRATION; MECHANISMS; MOVEMENT;
D O I
10.1038/srep40946
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent research in Alzheimer's disease (AD) indicates that perceptual impairments may occur before the onset of cognitive declines, and can thus serve as an early noninvasive indicator for AD. In this study, we focused on visual motion processing and explored whether AD induces changes in the properties of direction repulsion between two competing motions. We used random dot kinematograms (RDKs) and measured the magnitudes of direction repulsion between two overlapping RDKs moving different directions in three groups of participants: an AD group, an age-matched old control group, and a young control group. We showed that motion direction repulsion was significantly weaker in AD patients as comparing to both healthy controls. More importantly, we found that the magnitude of motion repulsion was predictive of the assessment of clinical severity in the AD group. Our results implicate that AD pathology is associated with altered neural functions in visual cortical areas and that motion repulsion deficit is a behavioral biomarker for the tracking of AD development.
引用
收藏
页数:6
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