Effects of Total Sleep Deprivation on Mouse Cytokine Levels

被引：2
|
作者：
Yang, Lin [1 ]
Li, Li [1 ]
Xue, Jianfeng [2 ]
机构：
[1] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Pest Management, Beijing, Peoples R China
[2] Beijing Kanghekechuang Biotech Co Ltd, Beijing, Peoples R China
来源：
NEUROIMMUNOMODULATION | 2016年 / 23卷 / 04期
关键词：
Cytokines; Total sleep deprivation; Mice; T-CELL; RATS; NEUROGENESIS; INFLAMMATION; RESTRICTION; IMMUNE; STRESS; BRAIN; HIPPOCAMPUS; RESPONSES;
D O I：
10.1159/000452713
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: Cytokines play an integral role in sleep/wake regulation. The objective of this study was to identify how total sleep deprivation affects cytokine levels. Methods: Male C57BL/6 mice were subjected to 48 h of total sleep deprivation produced by brief rotation of activity wheels or 3 different controls: home cage, a sedentary wheel, or forced activity. In addition, the serum levels of cytokines were analyzed using a mouse magnetic bead-based multiplex immunoassay. Results: The concentrations of some cytokines (fibro-blast growth factor-basic [FGF-basic], leukemia inhibitory factor [LIF], and monokine induced by interferon-gamma [MIG]) decreased significantly after total sleep deprivation. However, other cytokines (macrophage colony-stimulating factor, macrophage inflammatory protein-2, platelet-derived growth factor-bb, vascular endothelial growth factor) did not show any significant difference. Serum corticosterone levels did not differ significantly among the groups. Conclusion: The biochemical mechanisms responsible for sleep regulation are very complex. These results suggest the involvement of 3 cytokines (FGF-basic, LIF, and MIG) in sleep/wake regulation. (C) 2016 S. Karger AG, Basel
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页码：244 / 249
页数：6
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