Radioprotective effects of sodium tungstate on hematopoietic injury by exposure to 60Co γ-rays in Wistar rats

被引:9
|
作者
Sato, K
Ichimasa, M
Miyahara, K
Shiomi, M
Nishimura, Y
Ichimasa, Y [1 ]
机构
[1] Ibaraki Univ, Fac Sci, Dept Environm Sci, Mito, Ibaraki 3108512, Japan
[2] Natl Inst Agrobiol Resources, Inst Radiat Breeding, Oomiya 3192293, Japan
[3] Natl Inst Radiol Sci, Inage Ku, Chiba 2638555, Japan
关键词
radioprotection; sodium tungstate; rats; hematocrit value; gamma-rays;
D O I
10.1269/jrr.40.101
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Radioprotective effects of sodium tungstate (ST) on Co-60 gamma-ray induced decrease in hematocrit value and in survival rate in Wistar strain male rats were examined. A long term administration of ST (less than 150 mg/kg body weight/day) for 60-300 days had no significant effects on body and organs weights and survival days. The LD50/60 in 20 weeks old rats was 220 mg/kg body weight/day. Daily administration of 38, 75 or 150 mg from 7 days before and after irradiation to 60 days significantly mitigated the decrease in hematocrit values, especially at 23 days after irradiation (P<0.05). The highest mitigation rate of the decrease in hematocrit value was observed in rats administered at a dose of 38 mg ST/day. Simultaneously, a dose of 38 mg ST/day inhibited lethal effect of Co-60 gamma-rays significantly. The dose-reduction factor for survival of 38 mg ST administered rats was 1.14.
引用
收藏
页码:101 / 113
页数:13
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