The polymorphism rs763780 in the IL-17F gene is associated with response to biological drugs in patients with psoriasis

被引：43

作者：

Prieto-Perez, Rocio ^{[1
]}

Solano-Lopez, Guillermo ^{[2
]}

Cabaleiro, Teresa ^{[1
,3
]}

Roman, Manuel ^{[1
]}

Ochoa, Dolores ^{[1
]}

Talegon, Maria ^{[1
]}

Baniandres, Ofelia ^{[4
]}

Lopez Estebaranz, Jose Luis ^{[5
]}

de la Cueva, Pablo ^{[6
]}

Dauden, Esteban ^{[2
]}

Abad-Santos, Francisco ^{[1
,3
]}

机构：

[1] Univ Autonoma Madrid, Inst Invest Sanitaria Princesa IP, Hosp Univ Princesa, Clin Pharmacol Serv,Inst Teofilo Hernando, Madrid, Spain

[2] Hosp Univ Princesa, Inst Invest Sanitaria Princesa IP, Dermatol Serv, Madrid, Spain

[3] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepaticas & Di, Madrid 28029, Spain

[4] Hosp Univ Gregorio Maranon, Dermatol Serv, Madrid 28007, Spain

[5] Hosp Univ Fdn Alcorcon, Dermatol Serv, Madrid 28922, Spain

[6] Hosp Univ Infanta Leonor, Dermatol Serv, Madrid 28031, Spain

来源：

PHARMACOGENOMICS | 2015年 / 16卷 / 15期

关键词：

adalimumab; etanercept; IL-17; infliximab; pharmacogenetics; psoriasis; rs763780; rs10484879; rs2275913; ustekinumab; ANTI-TNF THERAPY; INTERLEUKIN; 17A; SUSCEPTIBILITY; ARTHRITIS; IL17A; ASTHMA;

D O I：

10.2217/pgs.15.107

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Psoriasis improves when IL-17 is blocked. Anti-TNF drugs reduce the IL-17 signaling pathway, and anti-IL-17 drugs are being developed to treat moderate-to-severe psoriasis. We analyzed three SNPs in IL-17A (rs2275913 and rs10484879) and IL-17F (rs763780) to look for an association with psoriasis and/or with response to anti-TNF drugs or ustekinumab. We included 197 healthy controls and 194 patients with moderate-to-severe psoriasis. The results of the univariate analysis showed an association between rs10484879 and psoriasis, although this relationship disappeared after adjustment for HLA-C (rs12191877). We also found an association between rs763780 (IL-17F) and response to ustekinumab (n = 70) and infliximab (n = 37) at 3 and 6 months and an association between rs763780 and the response to adalimumab at 6 months (n = 67).

引用

页码：1723 / 1731

页数：9

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