A novel series of 3-O-carbamoyl erythromycin A derived analogs, labeled carbamolides, with activity versus resistant bacterial isolates of staphylococci (including macrolide and oxazolidinone resistant strains) and streptococci are reported. An (R)-2-aryl substituent on a pyrrolidine carbamate appeared to be critical for achieving potency against resistant strains. Crystal structures showed a distinct aromatic interaction between the (R)-2-aryl (3-pyridyl for 4d) substituent on the pyrrolidine and G2484 (G2505, Escherichia coli) of the Deinococcus radiodurans 50S ribosome (3.2 angstrom resolution). (C) 2013 Elsevier Ltd. All rights reserved.
机构:
Capital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Wang, Chenqian
Wang, Guirong
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Wang, Guirong
Huo, Fengmin
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Huo, Fengmin
Xue, Yi
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Xue, Yi
Jia, Junnan
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Jia, Junnan
Dong, Lingling
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Dong, Lingling
Zhao, Liping
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Zhao, Liping
Wang, Fen
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Wang, Fen
Huang, Hairong
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Capital Med Univ, Beijing Chest Hosp, Natl Clin Lab TB, Beijing Key Lab Drug Resistant TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
Huang, Hairong
Duan, Hongfei
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Capital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R ChinaCapital Med Univ, Beijing Chest Hosp, Dept TB, Beijing, Peoples R China
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Calif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USACalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
Luna, Breanna L.
Garcia, Javier A.
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Calif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USACalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
Garcia, Javier A.
Huang, Min
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Univ Kansas, High Throughput Screening Lab, 1501 Wakarusa Dr, Lawrence, KS 66045 USA
Univ Kansas, Dept Med Chem, 1501 Wakarusa Dr, Lawrence, KS 66045 USACalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
Huang, Min
Ewing, Peter J.
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Calif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USACalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
Ewing, Peter J.
Valentine, Sonya C.
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Calif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USACalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
Valentine, Sonya C.
Chu, Yi-Ming
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Calif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USACalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
Chu, Yi-Ming
Ye, Qi-Zhuang
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Univ Kansas, High Throughput Screening Lab, 1501 Wakarusa Dr, Lawrence, KS 66045 USA
Univ Kansas, Dept Med Chem, 1501 Wakarusa Dr, Lawrence, KS 66045 USA
Shenzhen Univ, Sch Med, 3688 Nanhai Ave, Shenzhen 518060, Guangdong, Peoples R ChinaCalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
Ye, Qi-Zhuang
Xu, H. Howard
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Calif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USACalif State Univ Los Angeles, Dept Biol Sci, 5151 State Univ Dr, Los Angeles, CA 90032 USA
机构:
Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Zhang, Chaoqun
Fu, Le
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Fu, Le
Zhu, Yuan
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Zhu, Yuan
Chen, Qigui
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Sun Yat Sen Univ, Dept Sch Med, Shenzhen Campus, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Chen, Qigui
Chen, Zetong
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Sun Yat Sen Univ, Dept Sch Med, Shenzhen Campus, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Chen, Zetong
Chang, Yung-Fu
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Cornell Univ, Coll Vet Med, Dept Populat Med & Diagnost Sci, Ithaca, NY USASun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Chang, Yung-Fu
Li, Yide
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Li, Yide
Yao, Mengjing
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Yao, Mengjing
Huang, Xinyi
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Huang, Xinyi
Jin, Li
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Sun Yat Sen Univ, Dept Sch Med, Shenzhen Campus, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Jin, Li
Gao, Xue
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Sun Yat Sen Univ, Dept Sch Med, Shenzhen Campus, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Gao, Xue
Zhang, Yiyu
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Zhang, Yiyu
Jin, Biao
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Jin, Biao
Chou, Shuli
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China
Chou, Shuli
Luo, Liang
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Sun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 7, Dept Crit Care Med, Shenzhen, Peoples R China