A genetic inference on cancer immune responsiveness

被引：21
|
作者：
Wang, Ena
Uccellini, Lorenzo
Marincola, Francesco M. [1 ]
机构：
[1] NIH, IDIS, Dept Transfus Med, Ctr Clin, Bldg 10, Bethesda, MD 20892 USA
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期
关键词：
cancer genetics; immunotherapy; immune responsiveness; cancer microenvironment; melanoma; SYSTEMIC-LUPUS-ERYTHEMATOSUS; METASTATIC MELANOMA; IMMUNOLOGICAL CONSTANT; ALLOGRAFT-REJECTION; THERAPY; IMMUNOTHERAPY; AUTOIMMUNITY; TISSUE; TUMORS;
D O I：
10.4161/onci.19531
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A cancer immune signature implicating good prognosis and responsiveness to immunotherapy was described that is observed also in other aspects of immune-mediated, tissue-specific destruction (TSD). Its determinism remains, however, elusive. Based on limited but unique clinical observations, we propose a multifactorial genetic model of human cancer immune responsiveness.
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页数：6
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