Effect of clinical and laboratory parameters on quality of life in celiac patients using celiac disease-specific quality of life scores

被引:4
|
作者
Lee, Jungmin [1 ]
Clarke, Kofi [1 ]
机构
[1] Allegheny Hlth Network, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA
关键词
Celiac disease; quality of life; vitamin D; vitamin E; irritable bowel syndrome; GLUTEN-FREE DIET; HEALTH; SUPPLEMENTATION; DIAGNOSIS; BURDEN; ADULTS; IMPACT; TRIAL;
D O I
10.1080/00365521.2017.1350283
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objectives: Health-related quality of life (HR-QOL) in patients with celiac disease is reduced compared to the general population. We investigated the association between HR-QOL and clinical, laboratory findings using the previously validated CD-QOL (celiac disease-specific quality of life) instrument in patients with celiac disease. To our knowledge, no study has previously explored the relationship between HR-QOL and clinical, laboratory parameters in celiac patients. Materials and methods: Patients who received care at the Allegheny Health Network Celiac Center, Pittsburgh, PA were asked to complete the CD-QOL questionnaire. A cross sectional study with predetermined clinical and laboratory parameters was performed. Data collected included IgA anti-tissue transglutaminase (tTG) antibody titers, iron studies, calcium, vitamin A, B12, 25 OH vitamin D, and E levels. Correlation between clinical findings and CD-QOL was also assessed. Results: Seventy-eight out of 124 patients who completed the questionnaire was included in the analysis. Patients with concomitant irritable bowel syndrome (IBS) had significantly reduced HR-QOL with CD-QOL score of 52.4 +/- 11.3 vs. 44.6 +/- 12.9 in those without IBS (p = .009). There was no difference in HR-QOL in relation to IgA tTG titers or vitamin D levels. Of note, there was a trend towards correlation between higher level of vitamin E and better QOL (r = -.236, p = .074). Conclusions: Celiac patients with concomitant IBS have reduced HR-QOL. There was no statistically significant association between HR-QOL and laboratory parameters or levels of micronutrients.
引用
收藏
页码:1235 / 1239
页数:5
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