Effects of implantation of three-dimensional engineered bone tissue with a vascular-like structure on repair of bone defects

被引：0

作者：

Nishi, Masanori ^{[1
]}

Matsumoto, Rena ^{[1
]}

Dong, Jian ^{[2
]}

Uemura, Toshimasa ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Tsukuba, Ibaraki 3058562, Japan

[2] Fudan Univ, Zhongshan Hosp, Dept Orthopaed Surg, Shanghai 200032, Peoples R China

来源：

APPLIED SURFACE SCIENCE | 2012年 / 262卷

关键词：

Bone regeneartion; Bone tissue engineering; Implantation; Mesenchymal stem cell; Three-dimentional culture; Rotating wall vessel bioreactor; MESENCHYMAL STEM-CELLS; MARROW-DERIVED CELLS; POROUS HYDROXYAPATITE; RWV BIOREACTOR; CULTURE; MATRIX; DIFFERENTIATION; TRANSPLANTATION; OSTEOGENESIS; FABRICATION;

D O I：

10.1016/j.apsusc.2012.01.092

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Previously, to create an implantable bone tissue associated with blood vessels, we co-cultured rabbit bone marrow mesenchymal stem cells (MSCs) with MSC-derived endothelial cells (ECs) within a porous polylactic acid-based scaffold utilizing a rotating wall vessel (RWV) bioreactor. Here, this engineered tissue was orthotopically implanted into defects made in femurs of immunodeficient rats, and histological analysis were carried out to examine the repair of the damage and the formation of bone around the implant. The bone defects were better repaired in the implanted group than control group after 3 weeks. The results indicate that the engineered bone could repair bone defects. (c) 2012 Elsevier B. V. All rights reserved.

引用

页码：60 / 63

页数：4

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