Tongue tremor in neurofascin-155 IgG4 seropositive chronic inflammatory polyradiculoneuropathy

被引:10
|
作者
Briani, Chiara [1 ]
Salvalaggio, Alessandro [1 ]
Ruiz, Marta [1 ]
Cacciavillani, Mario [2 ]
Rinaldi, Francesca [1 ]
Callegari, Ilaria [3 ]
Gasparotti, Roberto [4 ]
Franciotta, Diego [5 ]
机构
[1] Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35128 Padua, Italy
[2] SYNLAB, CEMES EMG Lab, Padua, Italy
[3] Univ Pavia, Monza Policlin & Pavia Mondino, Neurosci Consortium, Pavia, Italy
[4] Univ Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Brescia, Italy
[5] IRCCS Mondino Fdn, Lab Neuroimmunol, Pavia, Italy
关键词
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP); Neurofascin-155; Tremor; tongue; DEMYELINATING POLYNEUROPATHY;
D O I
10.1016/j.jneuroim.2019.01.017
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) with anti-neurofascin-155 antibodies is a subgroup of CIDP with tremor and poor response to intravenous immunoglobulins. A 23-year-old male presented with a 6-month history ataxic-stepping gait, stocking tactile hypoesthesia, areflexia, tremor at limbs and tongue. Neurophysiology and cerebrospinal fluid analysis supported the diagnosis of CIDP. Tongue EMG was negative. Serum was positive for neurofascin-155 IgG4. His symptoms improved with intravenous methylprednisolone and then immunoglobulins, but not the tremor. Neurofascin-155 antibodies binding to cerebellar neurons suggests its central origin. This is the first neurofascin-155 antibody-seropositive patient with also tongue tremor, who is candidate to rituximab.
引用
收藏
页码:178 / 180
页数:3
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