Basic fibroblast growth factor treatment for skin ulcerations in scleroderma

被引：0
|
作者：
Yamanaka, K
Inaba, T
Nomura, E
Hurwitz, D
Jones, DA
Hakamada, A
Isoda, K
Kupper, TS
Mizutani, H
机构：
[1] Mie Univ, Grad Sch Med, Dept Dermatol, Tsu, Mie 5148507, Japan
[2] Harvard Univ, Brigham & Womens Hosp, Skin Dis Res Ctr, Dept Dermatol, Boston, MA 02115 USA
来源：
CUTIS | 2005年 / 76卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
We report the use of topical application of recombinant human basic fibroblast growth factor (rhbFGF) to successfully treat therapy-resistant, chronic leg ulcers in scleroderma. Endothelial cell FGF receptors are directly stimulated by bFGF,also, bFGF promotes the regeneration of capillary-rich granulation tissue. We conclude that topical bFGF may be a powerful new pharmacologic tool for treating severe skin ulcers.
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页码：373 / 376
页数：4
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