Diffuse optical imaging using spatially and temporally modulated light

被引：195

作者：

O'Sullivan, Thomas D. ^{[1
]}

Cerussi, Albert E. ^{[1
]}

Cuccia, David J. ^{[2
]}

Tromberg, Bruce J. ^{[1
]}

机构：

[1] Univ Calif Irvine, Beckman Laser Inst & Med Clin, Laser Microbeam & Med Program LAMMP, Irvine, CA 92612 USA

[2] Modulated Imaging Inc, Irvine, CA USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

near infrared spectroscopy; tissue optics; functional imaging; frequency domain photon migration; spatial frequency domain imaging; multiple light scattering; PHOTON-DENSITY WAVES; CANCER NEOADJUVANT CHEMOTHERAPY; NEAR-INFRARED SPECTROSCOPY; TIME-RESOLVED REFLECTANCE; SURGICAL ADJUVANT BREAST; PRIMARY MEDICAL THERAPY; FREQUENCY-DOMAIN; PREOPERATIVE CHEMOTHERAPY; NONINVASIVE DETERMINATION; TURBID MEDIA;

D O I：

10.1117/1.JBO.17.7.071311

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The authors describe the development of diffuse optical imaging (DOI) technologies, specifically the use of spatial and temporal modulation to control near infrared light propagation in thick tissues. We present theory and methods of DOI focusing on model-based techniques for quantitative, in vivo measurements of endogenous tissue absorption and scattering properties. We specifically emphasize the common conceptual framework of the scalar photon density wave for both temporal and spatial frequency-domain approaches. After presenting the history, theoretical foundation, and instrumentation related to these methods, we provide a brief review of clinical and preclinical applications from our research as well as our outlook on the future of DOI technology. 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.7.071311]

引用

页数：14

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