Irritable Bowel Syndrome and the Elusive Mast Cells

被引：12
|
作者：
Theoharides, Theoharis C. [1 ,2 ,3 ,4 ,6 ]
Asadi, Shahrzad [1 ,5 ]
Chen, Jihong [7 ]
Huizinga, Jan D. [8 ]
机构：
[1] Tufts Univ, Sch Med, Dept Mol Physiol & Pharmacol, Mol Immunopharmacol & Drug Discovery Lab, Boston, MA 02111 USA
[2] Tufts Univ, Sackler Sch Grad Biomed Sci, Boston, MA 02111 USA
[3] Tufts Univ Sch, Dept Biochem, Boston, MA USA
[4] Tufts Univ, Sch Med, Dept Internal Med, Boston, MA 02111 USA
[5] Tufts Med Ctr, Dept Pharm, Boston, MA USA
[6] Tufts Univ, Sch Med, Dept Psychiat, Boston, MA 02111 USA
[7] Wuhan Univ, Dept Gastroenterol, Renmin Hosp, Wuhan 430072, Peoples R China
[8] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Hamilton, ON, Canada
来源：
AMERICAN JOURNAL OF GASTROENTEROLOGY | 2012年 / 107卷 / 05期
基金：
加拿大健康研究院;
关键词：
ENDOTHELIAL GROWTH-FACTOR; DIFFERENTIAL RELEASE; ACUTE STRESS; ACTIVATION; IBS;
D O I：
10.1038/ajg.2012.61
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Irritable bowel syndrome (IBS) is the most common condition seen by gastroenterologists. It presents with alternating symptoms of bowel dysfunction that often worsens with stress. The cause of these symptoms eludes investigators and many attempts have been made to discover an underlying pathology. This is a daunting task since symptoms come and go, and change characteristics. Furthermore, the pathology of IBS is unlikely to be identical in all patients. In addition, all symptoms and all features studied thus far have a strong overlap with healthy volunteers. Elsewhere in this issue, Braak et al. report a well-designed clinical investigation in patients with IBS and come to the conclusion that IBS is not characterized by mast cell or other immune cell proliferation, but by immune dysregulation in the colon. Is this the final answer?
引用
收藏
页码：727 / 729
页数：3
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