Novel Composite Materials for Chiral Separation from Cellulose and Barium Sulfate

Cellulose was dissolved in an aqueous solution of sodium hydroxide (NaOH) and urea followed by the addition of barium sulfate (BaSO4) to yield the BaSO4/cellulose composite particles. The morphology, particle size, and BaSO4 content of the composite particles were adjusted by controlling the feed ratio of cellulose and BaSO4. The cellulose within the composite particles then reacted with 3,5-dimethylphenyl isocyanate. The resulting materials were utilized as the chiral stationary phases (CSPs) whose enantioseparation capabilities were evaluated by various chiral analytes. Due to the mechanical enhancement effect of BaSO4, the composite particles could be applied to the chromatographic packing materials.