Effect of serotonin 5-HT1A receptor agonists on sexual motivation of male mice

被引：1

作者：

Amstislavskaya, TG ^{[1
]}

Kucheryavyi, SA ^{[1
]}

Ivanova, EA ^{[1
]}

Popova, NK ^{[1
]}

机构：

[1] Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Lab Behav Phenogenet, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1999年 / 127卷 / 02期

关键词：

mice; sexual motivation; serotonin 5-HT1A receptors; hypothalamo-pituitary-gonadal complex; testosterone;

D O I：

10.1007/BF02433116

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The effect of selective agonists of serotonin 5-HT1A receptors on sexual arousal (its behavioral and hormonal components) in male CBA mice caused by estral females was studied, Injections of 8-OH-DPAT, flesinoxane, and ipsapirone significantly decreased the main behavioral parameter of sexual motivation (duration of the male's stay near the wall separating it from the receptive female). The activating effect of the female on the pituitary gonadal system of the male was completely blocked: the blood testosterone level did not increase. Therefore, the behavioral and hormonal components of sexual activation of males are regulated by the serotonin mechanisms alone, in which the cerebral 5-HT1A receptors are involved.

引用

页码：203 / 205

页数：3

共 50 条

[41] 5-HT1A AGONISTS DISRUPT MEMORY OF FEAR CONDITIONING IN MICE
QUARTERMAIN, D
CLEMENTE, J
SHEMER, A
BIOLOGICAL PSYCHIATRY, 1993, 33 (04) : 247 - 254
[42] Selective serotonin 5-HT1A receptor biased agonists elicitdistinct brain activation patterns: a pharmacoMRI study
G. Becker
R. Bolbos
N. Costes
J. Redouté
A. Newman-Tancredi
L. Zimmer
Scientific Reports, 6
[43] Agonists at the Serotonin Receptor (5-HT1A) Protect the Retina from Severe Photo-Oxidative Stress
Collier, Robert J.
Patel, Yamini
Martin, Elizabeth A.
Dembinska, Olga
Hellberg, Mark
Krueger, D. Scott
Kapin, Michael A.
Romano, Carmelo
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (05) : 2118 - 2126
[44] Activity of Serotonin 5-HT1A Receptor Biased Agonists in Rat: Anxiolytic and Antidepressant-like properties
Jastrzebska-Wiesek, Magdalena
Partyka, Anna
Rychtyk, Joanna
Sniecikowska, Joanna
Kolaczkowski, Marcin
Wesolowska, Anna
Varney, Mark A.
Newman-Tancredi, Adrian
ACS CHEMICAL NEUROSCIENCE, 2018, 9 (05): : 1040 - 1050
[45] Serotonin Transporter Null Mutation and Sexual Behavior in Female Rats: 5-HT1A Receptor Desensitization
Snoeren, Eelke
Chan, Johnny
Bovens, Astrid
Cuppen, Edwin
Waldinger, Marcel
Olivier, Berend
Oosting, Ronald
JOURNAL OF SEXUAL MEDICINE, 2010, 7 (07): : 2424 - 2434
[46] Imipramine but not 5-HT1A receptor agonists or neuroleptics induces adaptive changes in hippocampal 5-HT1A and 5-HT4 receptors
Zahorodna, A
Tokarski, K
Bijak, M
EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 443 (1-3) : 51 - 57
[47] SYNTHESIS OF METABOLICALLY STABLE ARYLPIPERAZINE 5-HT1A RECEPTOR AGONISTS
ROMERO, AG
DARLINGTON, WH
PIERCEY, MF
LAHTI, RA
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (12) : 1703 - 1706
[48] 5-HT1A RECEPTOR AGONISTS - RECENT DEVELOPMENTS AND CONTROVERSIAL ISSUES
DEVRY, J
PSYCHOPHARMACOLOGY, 1995, 121 (01) : 1 - 26
[49] WHEN AND HOW DO 5-HT1A AGONISTS FACILITATE SEXUAL-BEHAVIOR IN THE MALE-RAT
MOS, J
OLIVIER, B
PSYCHOPHARMACOLOGY, 1988, 96 (01) : S39 - S39
[50] Conservation of 5-HT1A receptor-mediated autoinhibition of serotonin (5-HT) neurons in mice with altered 5-HT homeostasis
Araragi, Naozumi
Mlinar, Boris
Baccini, Gilda
Gutknecht, Lise
Lesch, Klaus-Peter
Corradetti, Renato
FRONTIERS IN PHARMACOLOGY, 2013, 4

← 1 2 3 4 5 →