Three-Component Reaction o f 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

被引：4
|
作者：
Golantsov, Nikita E. [1 ]
Nguyen, Hung M. [1 ]
Golubenkova, Alexandra S. [1 ]
Varlamov, Alexey V. [1 ]
Van der Eycken, Erik V. [1 ,2 ]
Voskressensky, Leonid G. [1 ]
机构：
[1] RUDN Univ, Peoples Friendship Univ Russia, Fac Sci, Dept Organ Chem, Moscow, Russia
[2] Katholieke Univ Leuven, Univ Leuven, Dept Chem, LOMAC, Leuven, Belgium
来源：
FRONTIERS IN CHEMISTRY | 2019年 / 7卷
基金：
俄罗斯科学基金会;
关键词：
multicomponent reactions; isocyanides; indoleninium ions; aryl(indol-3-yl)methylium ions; imidates; MULTICOMPONENT REACTIONS SYNTHESIS; MICHAEL ADDITION; CYCLOADDITION; EFFICIENT; INDOLES; TOOL;
D O I：
10.3389/fchem.2019.00345
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesis of the above mentioned imidates from N-alkylindoles, aromatic aldehydes, aromatic isocyanides and alcohols was also proposed. In addition, it was shown that in the presence of water, aryl(indol-3-yl)methylium tetrafluoroborates reacted with isocyanides to furnish aryl(indol-3-yl)acetamides.
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页数：14
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