Three-Component Reaction o f 3-Arylidene-3H-Indolium Salts, Isocyanides, and Alcohols

被引：4

作者：

Golantsov, Nikita E. ^{[1
]}

Nguyen, Hung M. ^{[1
]}

Golubenkova, Alexandra S. ^{[1
]}

Varlamov, Alexey V. ^{[1
]}

Van der Eycken, Erik V. ^{[1
,2
]}

Voskressensky, Leonid G. ^{[1
]}

机构：

[1] RUDN Univ, Peoples Friendship Univ Russia, Fac Sci, Dept Organ Chem, Moscow, Russia

[2] Katholieke Univ Leuven, Univ Leuven, Dept Chem, LOMAC, Leuven, Belgium

来源：

FRONTIERS IN CHEMISTRY | 2019年 / 7卷

基金：

俄罗斯科学基金会;

关键词：

multicomponent reactions; isocyanides; indoleninium ions; aryl(indol-3-yl)methylium ions; imidates; MULTICOMPONENT REACTIONS SYNTHESIS; MICHAEL ADDITION; CYCLOADDITION; EFFICIENT; INDOLES; TOOL;

D O I：

10.3389/fchem.2019.00345

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel isocyanide-based multicomponent synthesis of alkyl aryl(indol-3-yl)acetimidates has been established. Starting from aryl(indol-3-yl)methylium tetrafluoroborates, aromatic isocyanides and alcohols, the imidates were obtained in moderate to very good yields. Consecutive four-component synthesis of the above mentioned imidates from N-alkylindoles, aromatic aldehydes, aromatic isocyanides and alcohols was also proposed. In addition, it was shown that in the presence of water, aryl(indol-3-yl)methylium tetrafluoroborates reacted with isocyanides to furnish aryl(indol-3-yl)acetamides.

引用

页数：14

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