Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria

被引：7
|
作者：
Shin, Sunny [1 ]
Argon, Yair [2 ,3 ]
机构：
[1] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[3] Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
IMMUNITY | 2015年 / 43卷 / 03期
关键词：
THIOREDOXIN-INTERACTING PROTEIN; ER STRESS; NLRP3; INFLAMMASOME; CELL-DEATH;
D O I：
10.1016/j.immuni.2015.08.027
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. Bronner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum stress sensor, IRE1 alpha, initiates NLRP3- and caspase-2-mediated mitochondrial damage that potentiates NLRP3 inflammasome assembly.
引用
收藏
页码：409 / 411
页数：3
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