Stressed-Out Endoplasmic Reticulum Inflames the Mitochondria

被引：7

作者：

Shin, Sunny ^{[1
]}

Argon, Yair ^{[2
,3
]}

机构：

[1] Univ Penn, Dept Microbiol, Perelman Sch Med, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[3] Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

IMMUNITY | 2015年 / 43卷 / 03期

关键词：

THIOREDOXIN-INTERACTING PROTEIN; ER STRESS; NLRP3; INFLAMMASOME; CELL-DEATH;

D O I：

10.1016/j.immuni.2015.08.027

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. Bronner et al. (2015) show that during Brucella abortus infection, an endoplasmic reticulum stress sensor, IRE1 alpha, initiates NLRP3- and caspase-2-mediated mitochondrial damage that potentiates NLRP3 inflammasome assembly.

引用

页码：409 / 411

页数：3

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