Copper-Mediated Oxidative Functionalization of C(sp3)-H Bonds with Isoquinolines: Two-Step Synthesis of 5-Oxaprotoberberinones

被引：2

作者：

Wang, Dingyi ^{[1
]}

Zhang, Rongxing ^{[1
]}

Deng, Ruihong ^{[1
]}

Lin, Sen ^{[1
]}

Guo, Shengmei ^{[1
]}

Yan, Zhaohua ^{[1
]}

机构：

[1] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 22期

基金：

中国国家自然科学基金;

关键词：

C-H AMINATION; EFFICIENT SYNTHESIS; METAL-FREE; AMIDATION; HYDROCARBONS; CYCLIZATION; ROSETTACIN; ACTIVATION; ANNULATION; ALKALOIDS;

D O I：

10.1021/acs.joc.6b02145

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-mediated oxidative functionalization of C(sp(3))-H bonds with isoquinolines via a radical process without ligands was achieved. The present system exhibits a novel pathway for the preparation of N-alkyl (benzyl) isoquinolin-1(2H)-ones in moderate to high yields. In addition, this procedure provides a simple method to afford 5-oxaprotoberberinones and their derivatives in two steps.

引用

页码：11162 / 11167

页数：6

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