Retinol palmitate protects against myocardial ischemia/reperfusion injury via reducing oxidative stress and inhibiting apoptosis

被引：2
|
作者：
Tao, Luyuan [1 ,3 ]
Huang, Kaiyu [1 ]
Wang, Jiaoni [1 ]
Xue, Yangjing [1 ]
Zhou, Yingying [1 ]
He, Fei [1 ]
Shen, Yigen [1 ]
Wang, Jinsheng [1 ]
Gu, Xingjian [3 ]
Ji, Kangting [1 ]
Qian, Lu [1 ]
Guo, Xianyang [2 ]
机构：
[1] Wenzhou Med Univ, Dept Cardiol, Affiliated & Yuying Childrens Hosp 2, Xueyuanxi Rd 109, Wenzhou 325000, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Intens Care Unit, Affiliated & Yuying Childrens Hosp 2, Xueyuanxi Rd 109, Wenzhou 325000, Zhejiang, Peoples R China
[3] Wenzhou Med Univ, Dept Cardiol, Huangyan Hosp, Hengjie Rd 218, Taizhou 318020, Zhejiang, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2019年 / 11卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Retinol palmitate; antioxidant; apoptosis; myocardial ischemia reperfusion injury; VITAMIN-A; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ACTIVITY; REPERFUSION INJURY; CELLULAR DEFENSES; FREE-RADICALS; RAT HEARTS; ISCHEMIA; INFARCTION; DAMAGE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The purpose of this study was to determine whether retinol palmitate could protect against myocardial ischemia/reperfusion (I/R) injury and explore the underlying mechanism. Retinol palmitate reduced the level of reactive oxygen species and prevented cellular apoptosis. In vivo, retinol palmitate increased superoxide dismutase (SOD) activity and reduced the level of malondialdehyde in I/R mice. Retinol palmitate also decreased myocardial infarct size and reduced cellular apoptosis by suppressing the expression of proapoptotic-related proteins and increasing that of SOD-related proteins. Our results suggest that retinol palmitate pretreatment has a protective effect against myocardial I/R injury by maintaining the balance between intracellular oxidants and antioxidants.
引用
收藏
页码：1510 / 1520
页数：11
相关论文
共 50 条
  • [31] CaMKII δ Deletion Protects Against Apoptosis In Myocardial Ischemia/Reperfusion Injury In Vivo
    Ling, Haiyun
    Zhang, Tong
    Brown, Joan Heller
    FASEB JOURNAL, 2008, 22
  • [32] Activated Protein C Protects Against Myocardial Ischemia/Reperfusion Injury via Inhibition of Apoptosis and Inflammation
    Loubele, Sarah T. B. G.
    Spek, C. Arnold
    Leenders, Peter
    van Oerle, Rene
    Aberson, Hella L.
    Hamulyak, Karly
    Ferrell, Gary
    Esmon, Charles T.
    Spronk, Henri M. H.
    ten Cate, Hugo
    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2009, 29 (07) : 1087 - U159
  • [33] Progranulin protects against cerebral ischemia-reperfusion (I/R) injury by inhibiting necroptosis and oxidative stress
    Li, Xiaogang
    Cheng, Shaoli
    Hu, Hao
    Zhang, Xiaotian
    Xu, Jiehua
    Wang, Rui
    Zhang, Pengbo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 521 (03) : 569 - 576
  • [34] Fibroblast Growth Factor 21 Protects Against Cerebral Ischemia/Reperfusion Injury by Inhibiting Oxidative Stress and Ferroptosis
    Li, Junjie
    Jiang, Haiyan
    Bai, Wenya
    Yang, Yuan
    Zhou, Guilin
    Chen, Wendong
    Shao, Jianlin
    NEUROPSYCHIATRIC DISEASE AND TREATMENT, 2025, 21 : 355 - 371
  • [35] Garcinol protects against cerebral ischemia-reperfusion injury in vivo and in vitro by inhibiting inflammation and oxidative stress
    Kang, Yingchao
    Sun, Yaping
    Li, Tiantian
    Ren, Zelin
    MOLECULAR AND CELLULAR PROBES, 2020, 54
  • [36] Alamandine protects against renal ischaemia-reperfusion injury in rats via inhibiting oxidative stress
    Zhu, Jue
    Qiu, Jian-Guo
    Xu, Wei-Tao
    Ma, Hong-Xiang
    Jiang, Ke
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2021, 73 (11) : 1491 - 1502
  • [37] 25-Hydroxycholesterol protects against myocardial ischemia-reperfusion injury via inhibiting PARP activity
    Lv, Suying
    Ju, Chenhui
    Peng, Jiangtong
    Liang, Minglu
    Zhu, Feng
    Wang, Cheng
    Huang, Kai
    Cheng, Min
    Zhang, Fengxiao
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2020, 16 (02): : 298 - 308
  • [38] Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress
    Lu, Qing
    Xia, Ning
    Xu, Hui
    Guo, Lianjun
    Wenzel, Philip
    Daiber, Andreas
    Muenzel, Thomas
    Foerstermann, Ulrich
    Li, Huige
    NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2011, 24 (03): : 132 - 138
  • [39] Hyperoside protects against cerebral ischemia-reperfusion injury by alleviating oxidative stress, inflammation and apoptosis in rats
    He, Jinting
    Li, Haiqi
    Li, Gaofeng
    Yang, Le
    BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2019, 33 (01) : 798 - 806
  • [40] Kaempferol Protects Against Cerebral Ischemia Reperfusion Injury Through Intervening Oxidative and Inflammatory Stress Induced Apoptosis
    Wang, Jing
    Mao, Junqin
    Wang, Rong
    Li, Shengnan
    Wu, Bin
    Yuan, Yongfang
    FRONTIERS IN PHARMACOLOGY, 2020, 11
12345