Therapeutic novelties in migraine: new drugs, new hope?

被引：92
|
作者：
Thien Phu Do [1 ,2 ]
Guo, Song [1 ,2 ]
Ashina, Messoud [1 ,2 ]
机构：
[1] Univ Copenhagen, Fac Hlth Sci, Rigshosp Glostrup, Danish Headache Ctr, Copenhagen, Denmark
[2] Univ Copenhagen, Fac Hlth Sci, Rigshosp Glostrup, Dept Neurol, Copenhagen, Denmark
来源：
JOURNAL OF HEADACHE AND PAIN | 2019年 / 20卷 / 1期
关键词：
Migraine; Randomized clinical trial; Efficacy; Tolerability; Adverse event; Ditan; Gepant; Antibody; CYCLASE-ACTIVATING POLYPEPTIDE; GENE-RELATED PEPTIDE; DOUBLE-BLIND; SPINAL-CORD; AGONIST; RECEPTOR; SUMATRIPTAN; EXPRESSION; EFFICACY; PROFILE;
D O I：
10.1186/s10194-019-0974-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
BackgroundIn the past decade, migraine research has identified novel drug targets. In this review, we discuss recent data on emerging anti-migraine therapies.Main bodyThe development of ditans, gepants and anti-calcitonin gene-related peptide monoclonal antibodies for the treatment of migraine is one of the greatest advances in themigraine field. Lasmiditan, rimegepant and ubrogepant will extend our therapeutic armamentarium for managing acute migraine attacks when triptans are not effective or contraindicated due to cardiovascular disorders. The monoclonal antibodies are migraine specific prophylactic drugs with high responder rates and favorable adverse event profiles. Furthermore, they offer convenient treatment regimens of 4- or 12-week intervals.ConclusionCollectively, novel migraine therapies represent a major progress in migraine treatment and will undoubtedly transform headache medicine.
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页数：13
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