Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p

被引：49
|
作者：
Zhang, Jian [1 ]
Liu, Hua [1 ]
Zhao, Ping [1 ]
Zhou, Hao [1 ]
Mao, Tao [1 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Dept Gen Surg, 16 Jiangsu Rd, Qingdao 266003, Shandong, Peoples R China
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2019年 / 120卷 / 03期
基金：
中国国家自然科学基金;
关键词：
circRNA; colon cancer; hsa_circ_0055625; ITGB8; miR-106b; COLORECTAL-CANCER; EXPRESSION; PROMOTES;
D O I：
10.1002/jcb.27355
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Circular RNAs (circRNA) are endogenous noncoding RNAs and play important roles in cancer; however, the roles of circRNAs in colon cancer are far from clear. The circRNA expression profile in colon cancer tissues was analyzed by microarray. The data from microarray showed that there were 198 upregulated and 136 downregulated circRNAs in colon cancer tissues. Among the top 10 upregulated circRNAs, hsa_circ_0055625 (circ_0055625) was confirmed to be significantly upregulated in colon cancer tissues. Further analysis demonstrated that circ_0055625 might get involved in the pathogenesis of colon cancer by functioning as miRNA sponges and performed bioinformatics analysis of the predicted circ_0055625/miR-106b-5p (miR-106b)/ITGB8 network. Moreover, we found that circ_0055625 expression was associated with pathological TNM stage and metastasis. These data indicated that circ_0055625/miR-106b/ITGB8 played a role in promoting tumor growth and metastasis, which suggested that circ_0055625 was a potential biomarker of colon cancer.
引用
收藏
页码：3027 / 3037
页数：11
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