Regenerative medicine for the treatment of heart disease

被引:17
|
作者
Hansson, E. M. [1 ,2 ]
Lendahl, U. [3 ]
机构
[1] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
[2] Massachusetts Gen Hosp, Cardiovasc Res Ctr, Richard B Simches Res Ctr CPZN 3200, Boston, MA 02114 USA
[3] Karolinska Inst, Dept Cell & Mol Biol, Stockholm, SE, Sweden
基金
瑞典研究理事会;
关键词
biomaterials; cell therapy; ES cell; iPS cell; myocardial infarction; stem cell; EMBRYONIC STEM-CELLS; BONE-MARROW-CELLS; ELEVATION MYOCARDIAL-INFARCTION; PROGENITOR CELLS; FUNCTIONAL-PROPERTIES; ISCHEMIC-HEART; CARDIOMYOCYTES; INTRACORONARY; FIBROBLASTS; TRANSPLANTATION;
D O I
10.1111/joim.12033
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hansson EM, Lendahl U (Harvard University, Cambridge, USA; Massachusetts General Hospital, Boston, USA; Karolinska Institute, Stockholm, Sweden). Regenerative medicine for the treatment of heart disease (Review). J Intern Med 2013; 273: 235-245. Heart failure is a major cause of mortality worldwide with a steady increase in prevalence. There is currently no available cure beyond orthotopic heart transplantation, which for a number of reasons is an option only for a small fraction of all patients. Considerable hope has therefore been placed on the possibility of treating a failing heart by replacing lost cardiomyocytes, either through transplantation of various types of stem cells or by boosting endogenous regenerative mechanisms in the heart. Here, we review the current status of stem and progenitor cell-based therapies for heart disease. We discuss the pros and cons of different stem and progenitor cell types that can be considered for transplantation and describe recent advances in the understanding of how cardiomyocytes normally differentiate and how these cells can be generated from more immature cells ex vivo. Finally, we consider the possibility of activation of endogenous stem and progenitor cells to treat heart failure.
引用
收藏
页码:235 / 245
页数:11
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