CYP3A4 HUMANIZED MOUSE; A MODEL TO STUDY CYP3A4-MEDIATED DRUG-DRUG INTERACTION POTENTIAL

被引:0
|
作者
Rose, Anne [1 ]
Xu, Carrie [1 ]
Johnghar, Susan [1 ]
Behnia, Kamelia [1 ]
机构
[1] Bristol Myers Squibb Co, New York, NY 10154 USA
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:76 / 77
页数:2
相关论文
共 50 条
  • [31] Physiologically-based pharmacokinetic modeling to predict CYP3A4-mediated drug-drug interactions of finerenone
    Wendl, Thomas
    Frechen, Sebastian
    Gerisch, Michael
    Heinig, Roland
    Eissing, Thomas
    CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2022, 11 (02): : 199 - 211
  • [32] Pharmacokinetic Evaluation of the CYP3A4 and CYP2D6 Drug-Drug Interaction and CYP3A4 Induction Potential of Omecamtiv Mecarbil: Two Open-Label Studies in Healthy Subjects
    Trivedi, Ashit
    Malik, Fady, I
    Jafarinasabian, Pegah
    Zhang, Hanze
    Flach, Stephen
    Abbasi, Siddique
    Dutta, Sandeep
    Lee, Edward
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2022, 11 (02): : 185 - 193
  • [33] Analysis of the Bile Acid Composition in a Fibroblast Growth Factor 19-Expressing Liver-Humanized Mouse Model and Its Use for CYP3A4-Mediated Drug-Drug Interaction Studies
    Mezler, Mario
    Jones, Robert S.
    Sangaraju, Dewakar
    Goldman, Devorah C.
    Hoffmann, Matthew
    Heikkinen, Aki T.
    Mannila, Janne
    Chang, Jae H.
    Foquet, Lander
    Pusalkar, Sandeepraj
    Chothe, Paresh P.
    Scheer, Nico
    DRUG METABOLISM AND DISPOSITION, 2023, 51 (10) : 1391 - 1402
  • [34] Effect of methylprednisolone on CYP3A4-mediated drug metabolism in vivo
    Krisper P.
    Aschauer M.
    Tiesenhausen K.
    Leitner G.
    Holzer H.
    Schneditz D.
    European Journal of Clinical Pharmacology, 2001, 57 (6) : 457 - 460
  • [35] Use of a Physiologically Based Pharmacokinetic Model for Quantitative Prediction of Drug-Drug Interactions via CYP3A4 and Estimation of the Intestinal Availability of CYP3A4 Substrates
    Mano, Yoko
    Sugiyama, Yuichi
    Ito, Kiyomi
    JOURNAL OF PHARMACEUTICAL SCIENCES, 2015, 104 (09) : 3183 - 3193
  • [36] Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development
    Sinz, Michael W.
    DRUG METABOLISM REVIEWS, 2013, 45 (01) : 3 - 14
  • [37] Investigation into CYP3A4-mediated drug–drug interactions on midostaurin in healthy volunteers
    Catherine Dutreix
    Florence Munarini
    Sebastien Lorenzo
    Johannes Roesel
    Yanfeng Wang
    Cancer Chemotherapy and Pharmacology, 2013, 72 : 1223 - 1234
  • [38] Pharmacokinetic drug-drug interaction between ethinyl estradiol and gestodene, administered as a transdermal fertility control patch, and two CYP3A4 inhibitors and a CYP3A4 substrate
    Winkler, Julia
    Goldammer, Mark
    Ludwig, Matthias
    Rohde, Beate
    Zurth, Christian
    EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2015, 40 (04) : 389 - 399
  • [39] Drug-Drug Interaction Studies to Evaluate the Effect of Inhibition of UGT1A1 and CYP3A4 and Induction of CYP3A4 on the Pharmacokinetics of Tropifexor in Healthy Subjects
    Chen, Jin
    Stringer, Rowan
    Shah, Bharti
    Gu, Jessie
    Zhang, Yiming
    Hackling, Melissa
    Prince, William
    Woessner, Ralph
    CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2022, 11 (11): : 1253 - 1263
  • [40] A new drug-drug interaction-tilmicosin reduces the metabolism of enrofloxacin through CYP3A4
    Zhang, Liyun
    Wang, XiaoJing
    Wang, Lei
    Badawy, Sara
    Liu, Zhenli
    Xie, Changqing
    Wang, Xu
    Tao, Yanfei
    RESEARCH IN VETERINARY SCIENCE, 2022, 148 : 33 - 41