Preoperative Lower Body Mass Index Correlates with Poorer Prognosis in Patients Undergoing Curative Laparoscopic Surgery for Colorectal Cancer

被引:0
|
作者
Uratani, Ryo [1 ]
Toiyama, Yuji [1 ]
Shimura, Tadanobu [1 ]
Mori, Koichiro [1 ]
Fujikawa, Hiroyuki [1 ]
Hiro, Jyunichiro [1 ]
Ohi, Masaki [1 ]
Inoue, Yasuhiro [1 ]
Tanaka, Koji [1 ]
Araki, Toshimitsu [1 ]
Mohri, Yasuhiko [1 ]
Kusunoki, Masato [1 ]
机构
[1] Mie Univ, Inst Life Sci, Grad Sch Med, Dept Gastrointestinal & Pediat Surg,Div Reparat M, Tsu, Mie 5148507, Japan
关键词
Colorectal cancer; laparoscopic surgery; body mass index; prognosis; recurrence; FATTY-ACID SYNTHASE; COLON-CANCER; LYMPHOCYTE RATIO; RANDOMIZED-TRIAL; METAANALYSIS; NEUTROPHIL; SURVIVAL; OBESITY; RECURRENCE; OVERWEIGHT;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim: The aim of this study was to investigate the correlations between clinicopathological findings, laboratory data and survival outcome in patients undergoing curative laparoscopic surgery for colorectal cancer (CRC). Patients and Methods: Clinicopathological findings and laboratory data, including tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) and systemic inflammatory response indicators, neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognosis score (mGPS), for 204 patients (tumor stage I-III) undergoing laparoscopic curative surgery for CRC were collected. Results: Elevated CA19-9 and mGPS, and body mass index (BMI) <20 kg/m(2) were significant indicators of poorer overall survival, while CA19-9 and BMI were validated as independent predictors of overall survival. In addition, BMI <20 kg/m(2) was a significant independent factor predictive of poorer disease-free survival. BMI significantly negatively correlated with NLR, which reflects the patients' immune response. Conclusion: Lower BMI is a promising predictor of recurrence and poor prognosis in patients treated by laparoscopic surgery for CRC with curative intent.
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收藏
页码:5639 / 5648
页数:10
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