miRNAs as biomarkers of neurodegenerative disorders

被引：60
|
作者：
Viswambharan, Vijitha [1 ]
Thanseem, Ismail [1 ]
Vasu, Mahesh M. [2 ]
Poovathinal, Suresh A. [3 ]
Anitha, Ayyappan [1 ]
机构：
[1] Inst Communicat & Cognit Neurosci ICCONS, Dept Neurogenet, Palakkad 679523, Kerala, India
[2] Hamamatsu Univ, Sch Med, Dept Psychiat, Hamamatsu, Shizuoka 4313192, Japan
[3] Inst Communicat & Cognit Neurosci ICCONS, Dept Neurol, Palakkad 679523, Kerala, India
来源：
BIOMARKERS IN MEDICINE | 2017年 / 11卷 / 02期
关键词：
Alzheimer's disease; amyotrophic lateral sclerosis; Friedreich's ataxia; Huntington's disease; miRNA; multiple sclerosis; Parkinson's disease; prion disease; spinal muscular atrophy; spinocerebellar ataxia; MULTIPLE-SCLEROSIS PATIENTS; MICRORNA EXPRESSION; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; CIRCULATING MICRORNAS; FRIEDREICH ATAXIA; GENETIC-ANALYSIS; BARRIER FUNCTION; RNA EXPRESSION; UP-REGULATION;
D O I：
10.2217/bmm-2016-0242
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Neurodegenerative diseases (NDDs) are the result of progressive deterioration of neurons, ultimately leading to disabilities. There is no effective cure for NDDs at present; ongoing therapies are mainly aimed at treating the most bothersome symptoms. Since early treatment is crucial in NDDs, there is an urgent need for specific and sensitive biomarkers that can aid in early diagnosis of these disorders. Recently, altered expression of miRNAs has been implicated in several neurological disorders, including NDDs. miRNA expression has been extensively investigated in the cells, tissues and body fluids of patients with different types of NDDs. The aim of this review is to provide a comprehensive overview of miRNAs as biomarkers and therapeutic targets for NDDs.
引用
收藏
页码：151 / 167
页数：17
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