Circadian rhythms and metabolism: from the brain to the gut and back again

被引：17

作者：

Cribbet, Matthew R. ^{[1
]}

Logan, Ryan W. ^{[1
]}

Edwards, Mathew D. ^{[2
]}

Hanlon, Erin ^{[3
]}

Peek, Clara Bien ^{[3
]}

Stubblefield, Jeremy J. ^{[4
]}

Vasudevan, Sridhar ^{[5
]}

Ritchey, Fiona ^{[1
]}

Frank, Ellen ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Med, Western Psychiat Inst & Clin, 3811 OHara St, Pittsburgh, PA 15213 USA

[2] MRC, Mol Biol Lab, Div Neurobiol, Cambridge, England

[3] Northwestern Univ, Feinberg Sch Med, Div Endocrinol Metab & Mol Med, Dept Med, Chicago, IL 60611 USA

[4] Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA

[5] Univ Oxford, Dept Pharmacol, Oxford, England

来源：

ANNALS REPORTS, VOL 1385 | 2016年 / 1385卷

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

circadian rhythms; metabolism; mood disorders; glucose; genetics; OBSTRUCTIVE SLEEP-APNEA; SUPRACHIASMATIC NUCLEUS; GLYCEMIC CONTROL; GENE-EXPRESSION; RNA POLYADENYLATION; GLUCOSE-TOLERANCE; ENERGY-METABOLISM; BIPOLAR DISORDER; PLASMA-GLUCOSE; CLOCK;

D O I：

10.1111/nyas.13188

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This paper focuses on the relationship between the circadian system and glucose metabolism. Research across the translational spectrum confirms the importance of the circadian system for glucose metabolism and offers promising clues as to when and why these systems go awry. In particular, basic research has started to clarify the molecular and genetic mechanisms through which the circadian system regulates metabolism. The study of human behavior, especially in the context of psychiatric disorders, such as bipolar disorder and major depression, forces us to see how inextricably linked mental health and metabolic health are. We also emphasize the remarkable opportunities for advancing circadian science through big data and advanced analytics. Advances in circadian research have translated into environmental and pharmacological interventions with tremendous therapeutic potential.

引用

页码：21 / 40

页数：20

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