Inhibition of Integrin α5β1 With the Small Peptide Atn-161 Reduces Infarct Volume and Improves Functional Recovery Through Reduction of Blood-brain Barrier Permeability

被引:0
|
作者
Edwards, Danielle
Salmeron, Kathleen
Fraser, Justin F.
Bix, Gregory J.
机构
关键词
Stroke; Efficacy; Endothelial; Reperfusion injury; Infarct size;
D O I
暂无
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
TMP28
引用
收藏
页数:2
相关论文
共 18 条
  • [1] Inhibition of [alpha]5[beta]1 Integrin With the Small Peptide ATN-161 Reduces Inflammation, Stabilizes the Blood-Brain Barrier, and is Neuroprotective After Experimental Ischemic Stroke
    Edwards, Danielle
    Salmeron, Katie
    Lukins, Doug
    Fraser, Justin F.
    Bix, Greg J.
    STROKE, 2019, 50
  • [2] Inhibition of α5β1integrin with the clinically validated small peptide, ATN-161 stabilizes cerebral vasculature, reduces inflammation, and decreases blood-brain barrier permeability after experimental ischemic stroke
    Edwards, Danielle
    Salmeron, Katie
    Lukins, Douglas
    Trout, Amanda
    Fraser, Justin
    Bix, Gregory
    FASEB JOURNAL, 2019, 33
  • [3] Inhibition of α5β1 integrin with ATN-161 is neuroprotective and stabilizes the blood-brain barrier after experimental ischemic stroke
    Edwards, D.
    Salmeron, K.
    Fraser, J.
    Bix, G. J.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2017, 37 : 269 - 269
  • [4] Integrin α5β1 inhibition by ATN-161 reduces neuroinflammation and is neuroprotective in ischemic stroke
    Edwards, Danielle N.
    Salmeron, Kathleen
    Lukins, Douglas E.
    Trout, Amanda L.
    Frasert, Justin F.
    Bix, Gregory J.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2020, 40 (08): : 1695 - 1708
  • [5] Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice
    Stoeltzing, O
    Liu, WB
    Reinmuth, N
    Fan, F
    Parry, GC
    Parikh, AA
    McCarty, MF
    Bucana, CD
    Mazar, AP
    Ellis, LM
    INTERNATIONAL JOURNAL OF CANCER, 2003, 104 (04) : 496 - 503
  • [6] ATN-161 reduces inflammation and blood-brain barrier dysfunction following in vitro stroke conditions in association with conservation of claudin-5 expression
    Edwards, D. N.
    Fraser, J. F.
    Bix, G. J.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2019, 39 : 34 - 35
  • [7] Inhibition of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Decreases Rat Cortical Neuron Injury and Blood-Brain Barrier Permeability, and Improves Neurological Functional Recovery in Traumatic Brain Injury Model
    Ding, Jun
    Guo, Jianyi
    Yuan, Qiang
    Yuan, Fang
    Chen, Hao
    Tian, Hengli
    PLOS ONE, 2013, 8 (11):
  • [8] Delayed Inhibition of VEGF Signaling after Stroke Attenuates Blood-Brain Barrier Breakdown and Improves Functional Recovery in a Comorbidity-Dependent Manner
    Reeson, Patrick
    Tennant, Kelly A.
    Gerrow, Kim
    Wang, Josh
    Novak, Sammy Weiser
    Thompson, Kelsey
    Lockhart, Krista-Linn
    Holmes, Andrew
    Nahirney, Patrick C.
    Brown, Craig E.
    JOURNAL OF NEUROSCIENCE, 2015, 35 (13): : 5128 - 5143
  • [9] Connexin43 mimetic peptide peptide5 reduces blood-brain barrier permeability in hemorrhagic transformation associated with delayed recombinant tissue plasminogen activator treatment in ischemic stroke
    Chu, H.
    Tang, Y.
    Dong, Q.
    CEREBROVASCULAR DISEASES, 2016, 41 : 263 - 263
  • [10] Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1α accumulation and VEGF expression
    Yeh, Wei-Lan
    Lu, Dah-Yuu
    Lin, Chun-Jung
    Liou, Houng-Chi
    Fu, Wen-Mei
    MOLECULAR PHARMACOLOGY, 2007, 72 (02) : 440 - 449